Peter R Young
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Explore the profile of Peter R Young including associated specialties, affiliations and a list of published articles.
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29
Citations
829
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0
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Recent Articles
1.
Babu S, Nicholson K, Rothstein J, Swenson A, Sampognaro P, Pant P, et al.
Brain
. 2024 Apr;
147(9):2998-3008.
PMID: 38606777
Apilimod dimesylate is a first-in-class phosphoinositide kinase, FYVE-type zinc finger-containing (PIKfyve) inhibitor with a favourable clinical safety profile and has demonstrated activity in preclinical C9orf72 and TDP-43 amyotrophic lateral sclerosis...
2.
Young P
Proc Int Astron Union
. 2020 Dec;
15(Suppl 350):333-340.
PMID: 33294002
The Sun's atmosphere increases in temperature from 6000 degrees at the surface to over a million degrees at heights of a few thousand kilometers. This surprising temperature increase is still...
3.
Beeharry N, Landrette S, Gayle S, Hernandez M, Grotzke J, Young P, et al.
Blood Adv
. 2019 Nov;
3(22):3661-3673.
PMID: 31751472
Acute myeloid leukemias (AML) harboring a constitutively active internal tandem duplication (ITD) mutation in the FMS-like kinase tyrosine kinase (FLT3) receptor are associated with poor patient prognosis. Despite initial clinical...
4.
Kharenko O, Patel R, Brown S, Calosing C, White A, Lakshminarasimhan D, et al.
J Med Chem
. 2018 Aug;
61(18):8202-8211.
PMID: 30165024
BET proteins are key epigenetic regulators that regulate transcription through binding to acetylated lysine (AcLys) residues of histones and transcription factors through bromodomains (BDs). The disruption of this interaction with...
5.
Jahagirdar R, Attwell S, Marusic S, Bendele A, Shenoy N, McLure K, et al.
Mol Pharmacol
. 2017 Oct;
92(6):694-706.
PMID: 28974538
Bromodomain (BD) and extra-terminal domain containing proteins (BET) are chromatin adapters that bind acetylated histone marks via two tandem BDs, BD1 and BD2, to regulate gene transcription. BET proteins are...
6.
Wasiak S, Gilham D, Tsujikawa L, Halliday C, Norek K, Patel R, et al.
Data Brief
. 2016 Aug;
8:1280-8.
PMID: 27570805
Apabetalone (RVX-208) inhibits the interaction between epigenetic regulators known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on histone tails. Data presented here supports the manuscript published in Atherosclerosis...
7.
Kharenko O, Gesner E, Patel R, Norek K, White A, Fontano E, et al.
Biochem Biophys Res Commun
. 2016 Jun;
477(1):62-67.
PMID: 27282480
Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential...
8.
Duffy B, Liu S, Martin G, Wang R, Hsia M, Zhao H, et al.
Bioorg Med Chem Lett
. 2015 May;
25(14):2818-23.
PMID: 26022843
Bromodomains are key transcriptional regulators that are thought to be druggable epigenetic targets for cancer, inflammation, diabetes and cardiovascular therapeutics. Of particular importance is the first of two bromodomains in...
9.
Verma R, Su S, McCrann D, Green J, Leu K, Young P, et al.
J Exp Med
. 2015 May;
212(6):971.
PMID: 25941257
No abstract available.
10.
Verma R, Su S, McCrann D, Green J, Leu K, Young P, et al.
J Exp Med
. 2014 Aug;
211(9):1715-22.
PMID: 25092874
Ligation of erythropoietin (EPO) receptor (EPOR) JAK2 kinase complexes propagates signals within erythroid progenitor cells (EPCs) that are essential for red blood cell production. To reveal hypothesized novel EPOR/JAK2 targets,...