Kevin G McLure
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Explore the profile of Kevin G McLure including associated specialties, affiliations and a list of published articles.
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13
Citations
729
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Recent Articles
1.
Ayyadurai V, Deonikar P, McLure K, Sakamoto K
Cancers (Basel)
. 2022 Feb;
14(3).
PMID: 35159023
A molecular systems architecture is presented for acute myeloid leukemia (AML) to provide a framework for organizing the complexity of biomolecular interactions. AML is a multifactorial disease resulting from impaired...
2.
Kharenko O, Patel R, Brown S, Calosing C, White A, Lakshminarasimhan D, et al.
J Med Chem
. 2018 Aug;
61(18):8202-8211.
PMID: 30165024
BET proteins are key epigenetic regulators that regulate transcription through binding to acetylated lysine (AcLys) residues of histones and transcription factors through bromodomains (BDs). The disruption of this interaction with...
3.
Jahagirdar R, Attwell S, Marusic S, Bendele A, Shenoy N, McLure K, et al.
Mol Pharmacol
. 2017 Oct;
92(6):694-706.
PMID: 28974538
Bromodomain (BD) and extra-terminal domain containing proteins (BET) are chromatin adapters that bind acetylated histone marks via two tandem BDs, BD1 and BD2, to regulate gene transcription. BET proteins are...
4.
Wasiak S, Gilham D, Tsujikawa L, Halliday C, Norek K, Patel R, et al.
Data Brief
. 2016 Aug;
8:1280-8.
PMID: 27570805
Apabetalone (RVX-208) inhibits the interaction between epigenetic regulators known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on histone tails. Data presented here supports the manuscript published in Atherosclerosis...
5.
Kharenko O, Gesner E, Patel R, Norek K, White A, Fontano E, et al.
Biochem Biophys Res Commun
. 2016 Jun;
477(1):62-67.
PMID: 27282480
Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential...
6.
Mitton B, Hsu K, Dutta R, Tiu B, Cox N, McLure K, et al.
Oncotarget
. 2016 Feb;
7(8):8653-62.
PMID: 26840025
The transcription factor CREB (cAMP Response Element Binding Protein) is an important determinant in the growth of Acute Myeloid Leukemia (AML) cells. CREB overexpression increases AML cell growth by driving...
7.
Duffy B, Liu S, Martin G, Wang R, Hsia M, Zhao H, et al.
Bioorg Med Chem Lett
. 2015 May;
25(14):2818-23.
PMID: 26022843
Bromodomains are key transcriptional regulators that are thought to be druggable epigenetic targets for cancer, inflammation, diabetes and cardiovascular therapeutics. Of particular importance is the first of two bromodomains in...
8.
Jahagirdar R, Zhang H, Azhar S, Tobin J, Attwell S, Yu R, et al.
Atherosclerosis
. 2014 Jul;
236(1):91-100.
PMID: 25016363
Despite the benefit of statins in reducing cardiovascular risk, a sizable proportion of patients still remain at risk. Since HDL reduces CVD risk through a process that involves formation of...
9.
Bhadury J, Nilsson L, Muralidharan S, Green L, Li Z, Gesner E, et al.
Proc Natl Acad Sci U S A
. 2014 Jul;
111(26):E2721-30.
PMID: 24979794
The bromodomain and extraterminal (BET) domain family of proteins binds to acetylated lysines on histones and regulates gene transcription. Recently, BET inhibitors (BETi) have been developed that show promise as...
10.
McLure K, Gesner E, Tsujikawa L, Kharenko O, Attwell S, Campeau E, et al.
PLoS One
. 2014 Jan;
8(12):e83190.
PMID: 24391744
Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the stimulation of reverse cholesterol transport. RVX-208 increases the production of...