Peter Felock
Overview
Explore the profile of Peter Felock including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
201
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0
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Recent Articles
1.
Gomez R, Jolly S, Williams T, Tucker T, Tynebor R, Vacca J, et al.
Bioorg Med Chem Lett
. 2011 Nov;
21(24):7344-50.
PMID: 22071300
Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones...
2.
Gomez R, Jolly S, Williams T, Vacca J, Torrent M, McGaughey G, et al.
J Med Chem
. 2011 Oct;
54(22):7920-33.
PMID: 21985673
Highly active antiretroviral therapy (HAART) significantly reduces human immunodeficiency virus (HIV) viral load and has led to a dramatic decrease in acquired immunodeficiency syndrome (AIDS) related mortality. Despite this success,...
3.
Wang Y, McKenna P, Hrin R, Felock P, Lu M, Jones K, et al.
J Virol Methods
. 2010 Feb;
165(2):230-7.
PMID: 20153375
Traditional phenotypic assays used to assess the susceptibility of mutant human immunodeficiency virus type-1 (HIV-1) obtained from infected patients or from resistance selection to antiviral agents in cell culture are...
4.
Munshi V, Lu M, Felock P, Barnard R, Hazuda D, Miller M, et al.
Anal Biochem
. 2007 Oct;
374(1):121-32.
PMID: 17964275
Reverse transcriptase (RT) plays an essential role in the HIV-1 replication process, which converts a single-strand RNA into a double-strand DNA via polymerase and RNase H activities. Therefore, inhibition of...
5.
Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, et al.
J Med Chem
. 2007 Sep;
50(20):4953-75.
PMID: 17824681
The human immunodeficiency virus type-1 (HIV-1) encodes three enzymes essential for viral replication: a reverse transcriptase, a protease, and an integrase. The latter is responsible for the integration of the...
6.
Singh S, Ondeyka J, Schleif W, Felock P, Hazuda D
J Nat Prod
. 2003 Oct;
66(10):1338-44.
PMID: 14575434
Integracides, 4,4-dimethylergostane triterpenoids, are inhibitors of HIV-1 integrase, a critical enzyme in replication of HIV-1. The chemistry and structure-activity relationship of integracide B and related natural products are described. A...
7.
Singh S, Zink D, Bills G, Teran A, Silverman K, Lingham R, et al.
Bioorg Med Chem Lett
. 2003 Mar;
13(4):713-7.
PMID: 12639565
Integration of viral DNA into host cell DNA is an essential step in retroviral (HIV-1) replication and is catalyzed by HIV-1 integrase. HIV-1 integrase is a novel therapeutic target and...
8.
Singh S, Zink D, Dombrowski A, Polishook J, Ondeyka J, Hirshfield J, et al.
Bioorg Med Chem
. 2003 Mar;
11(7):1577-82.
PMID: 12628681
HIV-1 integrase is a critical enzyme in the replication of HIV-1. It is absent in the host cells and therefore is a good target for treatment of HIV-1 infections. Integracides...
9.
Grobler J, Stillmock K, Hu B, Witmer M, Felock P, Espeseth A, et al.
Proc Natl Acad Sci U S A
. 2002 May;
99(10):6661-6.
PMID: 11997448
The process of integrating the reverse-transcribed HIV-1 DNA into the host chromosomal DNA is catalyzed by the virally encoded enzyme integrase (IN). Integration requires two metal-dependent reactions, 3' end processing...
10.
Singh S, Zink D, Heimbach B, Genilloud O, Teran A, Silverman K, et al.
Org Lett
. 2002 Apr;
4(7):1123-6.
PMID: 11922798
[structure: see text] HIV-1 integrase is a critical enzyme for viral replication, and its inhibition is an emerging target for potential antiviral chemotherapy. We have discovered a novel inhibitor, integramycin,...