Peter Duchek
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Explore the profile of Peter Duchek including associated specialties, affiliations and a list of published articles.
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14
Citations
676
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Recent Articles
1.
Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals
Baumgartner L, Ipsaro J, Hohmann U, Handler D, Schleiffer A, Duchek P, et al.
Elife
. 2024 Jul;
13.
PMID: 38995818
Members of the diverse heterochromatin protein 1 (HP1) family play crucial roles in heterochromatin formation and maintenance. Despite the similar affinities of their chromodomains for di- and tri-methylated histone H3...
2.
Pliota P, Marvanova H, Koreshova A, Kaufman Y, Tikanova P, Krogull D, et al.
Nature
. 2024 Mar;
628(8006):122-129.
PMID: 38448590
Genomic imprinting-the non-equivalence of maternal and paternal genomes-is a critical process that has evolved independently in many plant and mammalian species. According to kinship theory, imprinting is the inevitable consequence...
3.
Baumgartner L, Handler D, Platzer S, Yu C, Duchek P, Brennecke J
Elife
. 2022 Oct;
11.
PMID: 36193674
RNA interference systems depend on the synthesis of small RNA precursors whose sequences define the target spectrum of these silencing pathways. The Heterochromatin Protein 1 (HP1) variant Rhino permits transcription...
4.
Andreev V, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, et al.
Nat Struct Mol Biol
. 2022 Feb;
29(2):130-142.
PMID: 35173350
Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs are...
5.
Schnabl J, Wang J, Hohmann U, Gehre M, Batki J, Andreev V, et al.
Genes Dev
. 2021 Feb;
35(5-6):392-409.
PMID: 33574069
Nuclear Argonaute proteins, guided by their bound small RNAs to nascent target transcripts, mediate cotranscriptional silencing of transposons and repetitive genomic loci through heterochromatin formation. The molecular mechanisms involved in...
6.
Abramczuk M, Burkard T, Rolland V, Steinmann V, Duchek P, Jiang Y, et al.
Development
. 2017 Sep;
144(21):3932-3945.
PMID: 28935704
Stem cells need to balance self-renewal and differentiation for correct tissue development and homeostasis. Defects in this balance can lead to developmental defects or tumor formation. In recent years, mRNA...
7.
Asaoka T, Almagro J, Ehrhardt C, Tsai I, Schleiffer A, Deszcz L, et al.
EMBO Rep
. 2016 Oct;
17(11):1624-1640.
PMID: 27702987
The HOIP ubiquitin E3 ligase generates linear ubiquitin chains by forming a complex with HOIL-1L and SHARPIN in mammals. Here, we provide the first evidence of linear ubiquitination induced by...
8.
Wissel S, Kieser A, Yasugi T, Duchek P, Roitinger E, Gokcezade J, et al.
G3 (Bethesda)
. 2016 Jun;
6(8):2467-78.
PMID: 27280787
Traditional loss-of-function studies in Drosophila suffer from a number of shortcomings, including off-target effects in the case of RNA interference (RNAi) or the stochastic nature of mosaic clonal analysis. Here,...
9.
Akbari O, Bellen H, Bier E, Bullock S, Burt A, Church G, et al.
Science
. 2015 Aug;
349(6251):927-9.
PMID: 26229113
No abstract available.
10.
Gokcezade J, Sienski G, Duchek P
G3 (Bethesda)
. 2014 Sep;
4(11):2279-82.
PMID: 25236734
The CRISPR-associated RNA-guided nuclease Cas9 has emerged as a powerful tool for genome engineering in a variety of organisms. To achieve efficient gene targeting rates in Drosophila, current approaches require...