Karl Mechtler
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Explore the profile of Karl Mechtler including associated specialties, affiliations and a list of published articles.
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Articles
219
Citations
11362
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Recent Articles
1.
Birklbauer M, Muller F, Sivakumar Geetha S, Matzinger M, Mechtler K, Dorfer V
Commun Chem
. 2025 Feb;
8(1):62.
PMID: 40016320
No abstract available.
2.
Bubis J, Arrey T, Damoc E, Delanghe B, Slovakova J, Sommer T, et al.
Nat Methods
. 2025 Jan;
22(3):510-519.
PMID: 39820751
Despite significant advancements in sample preparation, instrumentation and data analysis, single-cell proteomics is currently limited by proteomic depth and quantitative performance. Here we demonstrate highly improved depth of proteome coverage...
3.
Tang W, Costantino L, Stocsits R, Wutz G, Ladurner R, Hudecz O, et al.
EMBO J
. 2025 Jan;
44(3):736-766.
PMID: 39748119
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is...
4.
Chiva C, Olivella R, Staes A, Mendes Maia T, Panse C, Stejskal K, et al.
J Proteome Res
. 2025 Jan;
24(2):397-409.
PMID: 39743223
Quality control procedures play a pivotal role in ensuring the reliability and consistency of data generated in mass spectrometry-based proteomics laboratories. However, the lack of standardized quality control practices across...
5.
Birklbauer M, Muller F, Sivakumar Geetha S, Matzinger M, Mechtler K, Dorfer V
Commun Chem
. 2024 Dec;
7(1):300.
PMID: 39702463
The field of crosslinking mass spectrometry has seen substantial advancements over the past decades, enabling the structural analysis of proteins and protein complexes and serving as a powerful tool in...
6.
Pajenda S, Gerges D, Wagner L, OConnell D, Aiad M, Imre R, et al.
Diagnostics (Basel)
. 2024 Aug;
14(15).
PMID: 39125467
Primary focal segmental glomerulosclerosis (FSGS) is a disease of the podocytes and glomerulus, leading to nephrotic syndrome and progressive loss of renal function. One of the most serious aspects is...
7.
Hartlmayr D, Ctortecka C, Mayer R, Mechtler K, Seth A
Methods Mol Biol
. 2024 Jun;
2817:1-7.
PMID: 38907142
In recent years, single-cell proteomics (SCP) has become a valuable addition to other single-cell omics technologies for studying cellular heterogeneity. The amount of protein in a single cell is very...
8.
Ctortecka C, Mechtler K
Anal Sci Adv
. 2024 May;
2(3-4):84-94.
PMID: 38716457
Mass spectrometry-based proteomics comprehensively defines proteome expression patterns in thousands of cells majorly contributing to our current understanding of many biological processes. More recently, single-cell transcriptome and genome studies, however,...
9.
Matzinger M, Schmucker A, Yelagandula R, Stejskal K, Krssakova G, Berger F, et al.
Nat Commun
. 2024 Feb;
15(1):1019.
PMID: 38310095
Comprehensive proteomic analysis is essential to elucidate molecular pathways and protein functions. Despite tremendous progress in proteomics, current studies still suffer from limited proteomic coverage and dynamic range. Here, we...
10.
Mayer R, Mechtler K
Biology (Basel)
. 2023 Dec;
12(12).
PMID: 38132340
Immunopeptidomics, as the analysis of antigen peptides being presented to the immune system via major histocompatibility complexes (MHC), is being seen as an imperative tool for identifying epitopes for vaccine...