Dominik Handler
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Explore the profile of Dominik Handler including associated specialties, affiliations and a list of published articles.
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16
Citations
1363
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Recent Articles
1.
Chavan A, Skrutl L, Uliana F, Pfister M, Brandle F, Tirian L, et al.
PLoS Biol
. 2025 Jan;
23(1):e3002984.
PMID: 39813297
Noncoding satellite DNA repeats are abundant at the pericentromeric heterochromatin of eukaryotic chromosomes. During interphase, sequence-specific DNA-binding proteins cluster these repeats from multiple chromosomes into nuclear foci known as chromocenters....
2.
Deneke V, Blaha A, Lu Y, Suwita J, Draper J, Phan C, et al.
Cell
. 2024 Oct;
187(25):7066-7078.e22.
PMID: 39423812
Fertilization, the basis for sexual reproduction, culminates in the binding and fusion of sperm and egg. Although several proteins are known to be crucial for this process in vertebrates, the...
3.
Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals
Baumgartner L, Ipsaro J, Hohmann U, Handler D, Schleiffer A, Duchek P, et al.
Elife
. 2024 Jul;
13.
PMID: 38995818
Members of the diverse heterochromatin protein 1 (HP1) family play crucial roles in heterochromatin formation and maintenance. Despite the similar affinities of their chromodomains for di- and tri-methylated histone H3...
4.
Wallner E, Mair A, Handler D, McWhite C, Xu S, Dolan L, et al.
Dev Cell
. 2024 Mar;
59(9):1096-1109.e5.
PMID: 38518768
Cell polarity is used to guide asymmetric divisions and create morphologically diverse cells. We find that two oppositely oriented cortical polarity domains present during the asymmetric divisions in the Arabidopsis...
5.
Pliota P, Marvanova H, Koreshova A, Kaufman Y, Tikanova P, Krogull D, et al.
Nature
. 2024 Mar;
628(8006):122-129.
PMID: 38448590
Genomic imprinting-the non-equivalence of maternal and paternal genomes-is a critical process that has evolved independently in many plant and mammalian species. According to kinship theory, imprinting is the inevitable consequence...
6.
Baumgartner L, Handler D, Platzer S, Yu C, Duchek P, Brennecke J
Elife
. 2022 Oct;
11.
PMID: 36193674
RNA interference systems depend on the synthesis of small RNA precursors whose sequences define the target spectrum of these silencing pathways. The Heterochromatin Protein 1 (HP1) variant Rhino permits transcription...
7.
Andreev V, Yu C, Wang J, Schnabl J, Tirian L, Gehre M, et al.
Nat Struct Mol Biol
. 2022 Feb;
29(2):130-142.
PMID: 35173350
Nuclear Argonaute proteins, guided by small RNAs, mediate sequence-specific heterochromatin formation. The molecular principles that link Argonaute-small RNA complexes to cellular heterochromatin effectors on binding to nascent target RNAs are...
8.
Grentzinger T, Oberlin S, Schott G, Handler D, Svozil J, Barragan-Borrero V, et al.
Nucleic Acids Res
. 2020 Jun;
48(14):e79.
PMID: 32496553
Diverse classes of silencing small (s)RNAs operate via ARGONAUTE-family proteins within RNA-induced-silencing-complexes (RISCs). Here, we have streamlined various embodiments of a Q-sepharose-based RISC-purification method that relies on conserved biochemical properties...
9.
Batki J, Schnabl J, Wang J, Handler D, Andreev V, Stieger C, et al.
Nat Struct Mol Biol
. 2019 Aug;
26(8):720-731.
PMID: 31384064
The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet...
10.
Hayashi R, Schnabl J, Handler D, Mohn F, Ameres S, Brennecke J
Nature
. 2016 Nov;
539(7630):588-592.
PMID: 27851737
Small regulatory RNAs guide Argonaute (Ago) proteins in a sequence-specific manner to their targets and therefore have important roles in eukaryotic gene silencing. Of the three small RNA classes, microRNAs...