Peter Csermely
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Explore the profile of Peter Csermely including associated specialties, affiliations and a list of published articles.
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129
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4396
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Recent Articles
1.
Kerestely M, Keresztes D, Szarka L, Kovacs B, Schulc K, Veres D, et al.
Br J Pharmacol
. 2025 Feb;
PMID: 39909489
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small-scale interactomes and signalling network models of...
2.
Keresztes D, Kerestely M, Szarka L, Kovacs B, Schulc K, Veres D, et al.
Biomed Pharmacother
. 2025 Jan;
183:117880.
PMID: 39884030
Drug resistance is a major cause of tumor mortality. Signaling networks became useful tools for driving pharmacological interventions against cancer drug resistance. Signaling datasets now cover the entire human cell....
3.
Veres T, Kerestely M, Kovacs B, Keresztes D, Schulc K, Seitz E, et al.
Cell Mol Life Sci
. 2024 Feb;
81(1):97.
PMID: 38372750
Recent findings show that single, non-neuronal cells are also able to learn signalling responses developing cellular memory. In cellular learning nodes of signalling networks strengthen their interactions e.g. by the...
4.
Hajdu G, Somogyvari M, Csermely P, Soti C
Commun Biol
. 2023 Sep;
6(1):936.
PMID: 37704756
Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes immunodeficiency. However, their primordial functions remain unclear. Here, we report that C. elegans LROs (gut granules) promote organismal defenses against...
5.
Varga A, Nguyen M, Penzes K, Batai B, Gyulavari P, Gurbi B, et al.
Cells
. 2023 Jan;
12(2).
PMID: 36672148
Prostate cancer metastasis is a significant cause of mortality in men. PKD3 facilitates tumor growth and metastasis, however, its regulation is largely unclear. The Hsp90 chaperone stabilizes an array of...
6.
Deritei D, Kunsic N, Csermely P
PLoS Comput Biol
. 2022 Oct;
18(10):e1010536.
PMID: 36215324
Biological systems are noisy by nature. This aspect is reflected in our experimental measurements and should be reflected in the models we build to better understand these systems. Noise can...
7.
Mendik P, Kerestely M, Kamp S, Deritei D, Kunsic N, Vassy Z, et al.
NPJ Syst Biol Appl
. 2022 Jun;
8(1):19.
PMID: 35680961
Regulation of translocating proteins is crucial in defining cellular behaviour. Epithelial-mesenchymal transition (EMT) is important in cellular processes, such as cancer progression. Several orchestrators of EMT, such as key transcription...
8.
Balogh O, Benczik B, Horvath A, Petervari M, Csermely P, Ferdinandy P, et al.
BMC Bioinformatics
. 2022 Feb;
23(1):78.
PMID: 35183129
Background: The investigation of possible interactions between two proteins in intracellular signaling is an expensive and laborious procedure in the wet-lab, therefore, several in silico approaches have been implemented to...
9.
Csabai L, Fazekas D, Kadlecsik T, Szalay-Beko M, Bohar B, Madgwick M, et al.
Nucleic Acids Res
. 2021 Oct;
50(D1):D701-D709.
PMID: 34634810
Signaling networks represent the molecular mechanisms controlling a cell's response to various internal or external stimuli. Most currently available signaling databases contain only a part of the complex network of...
10.
Bodor C, Kotmayer L, Laszlo T, Takacs F, Barna G, Kiss R, et al.
Br J Haematol
. 2021 May;
194(2):355-364.
PMID: 34019713
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in the BTK tyrosine kinase domain are...