Pere Roca-Cusachs
Overview
Explore the profile of Pere Roca-Cusachs including associated specialties, affiliations and a list of published articles.
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76
Citations
5973
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Recent Articles
1.
Perucca A, Llonin A, Benach O, Hallopeau C, Rivas E, Linares J, et al.
Nat Commun
. 2025 Feb;
16(1):1279.
PMID: 39900918
Immunotherapies are beneficial for a considerable proportion of cancer patients, but ineffective in others. In vitro modelling of the complex interactions between cancer cells and their microenvironment could provide a...
2.
Oliver-De La Cruz J, Roca-Cusachs P
Curr Biol
. 2025 Jan;
35(2):R76-R79.
PMID: 39837277
Mechanical forces influence mitochondrial dynamics through previously unexplored mechanisms. A new study demonstrates that actomyosin tension inhibits mitochondrial fission by phosphorylating a key component of the fission complex and that...
3.
Lee S, Le Roux A, Mors M, Vanni S, Roca-Cusachs P, Bahmanyar S
bioRxiv
. 2024 Nov;
PMID: 39605395
Amphipathic helices (AHs) are ubiquitous protein motifs that modulate targeting to organellar membranes by sensing differences in bulk membrane properties. However, the adaptation between membrane-targeting AHs and the nuclear membrane...
4.
Huerta-Lopez C, Clemente-Manteca A, Velazquez-Carreras D, Espinosa F, Sanchez J, Martinez-Del-Pozo A, et al.
Sci Adv
. 2024 Nov;
10(46):eadf9758.
PMID: 39546608
The mechanics of the extracellular matrix (ECM) determine cell activity and fate through mechanoresponsive proteins including Yes-associated protein 1 (YAP). Rigidity and viscous relaxation have emerged as the main mechanical...
5.
Faure L, Gomez-Gonzalez M, Baguer O, Comelles J, Martinez E, Arroyo M, et al.
Adv Sci (Weinh)
. 2024 Oct;
11(46):e2406932.
PMID: 39443837
Cell shape and function are intimately linked, in a way that is mediated by the forces exerted between cells and their environment. The relationship between cell shape and forces has...
6.
Barcelona-Estaje E, Oliva M, Cunniffe F, Rodrigo-Navarro A, Genever P, Dalby M, et al.
Nat Commun
. 2024 Oct;
15(1):8824.
PMID: 39394209
Mesenchymal stem cells (MSCs) interact with their surroundings via integrins, which link to the actin cytoskeleton and translate physical cues into biochemical signals through mechanotransduction. N-cadherins enable cell-cell communication and...
7.
Granero-Moya I, Venturini V, Belthier G, Groenen B, Molina-Jordan M, Gonzalez-Martin M, et al.
J Cell Sci
. 2024 Aug;
137(17).
PMID: 39120491
Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single adhesive cells, mechanotransduction involves the transmission of force from the extracellular matrix...
8.
Conti S, Venturini V, Canellas-Socias A, Cortina C, Abenza J, Stephan-Otto Attolini C, et al.
Nat Commun
. 2024 Apr;
15(1):3363.
PMID: 38637494
Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical...
9.
Beedle A, Jaganathan A, Albajar-Sigales A, Yavitt F, Bera K, Andreu I, et al.
bioRxiv
. 2023 Nov;
PMID: 37986921
The cell nucleus is continuously exposed to external signals, of both chemical and mechanical nature. To ensure proper cellular response, cells need to regulate not only the transmission of these...
10.
Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, et al.
Elife
. 2023 Sep;
12.
PMID: 37747150
As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To maintain homeostasis, cells need to detect and restore such...