Anabel-Lise Le Roux
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Explore the profile of Anabel-Lise Le Roux including associated specialties, affiliations and a list of published articles.
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13
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828
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Recent Articles
1.
Mohammad I, Giannotti M, Fourgous E, Boublik Y, Fernandez A, Le Roux A, et al.
Life Sci Alliance
. 2025 Mar;
8(5).
PMID: 40081987
Src tyrosine kinase regulates cell growth and adhesion through membrane signaling, and its deregulation is associated with cancer. Although active Src is anchored to the plasma membrane, the role of...
2.
Lee S, Le Roux A, Mors M, Vanni S, Roca-Cusachs P, Bahmanyar S
bioRxiv
. 2024 Nov;
PMID: 39605395
Amphipathic helices (AHs) are ubiquitous protein motifs that modulate targeting to organellar membranes by sensing differences in bulk membrane properties. However, the adaptation between membrane-targeting AHs and the nuclear membrane...
3.
Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, et al.
Elife
. 2023 Sep;
12.
PMID: 37747150
As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To maintain homeostasis, cells need to detect and restore such...
4.
Phuyal S, Djaerff E, Le Roux A, Baker M, Fankhauser D, Mahdizadeh S, et al.
EMBO J
. 2022 Aug;
41(18):e110596.
PMID: 35938214
Cells are constantly exposed to various chemical and physical stimuli. While much has been learned about the biochemical factors that regulate secretory trafficking from the endoplasmic reticulum (ER), much less...
5.
Le Roux A, Tozzi C, Walani N, Quiroga X, Zalvidea D, Trepat X, et al.
Nat Commun
. 2021 Nov;
12(1):6550.
PMID: 34772909
In many physiological situations, BAR proteins reshape membranes with pre-existing curvature (templates), contributing to essential cellular processes. However, the mechanism and the biological implications of this reshaping process remain unclear....
6.
Andreu I, Falcones B, Hurst S, Chahare N, Quiroga X, Le Roux A, et al.
Nat Commun
. 2021 Jul;
12(1):4229.
PMID: 34244477
Cell response to force regulates essential processes in health and disease. However, the fundamental mechanical variables that cells sense and respond to remain unclear. Here we show that the rate...
7.
Tozzi C, Walani N, Le Roux A, Roca-Cusachs P, Arroyo M
Soft Matter
. 2021 Mar;
17(12):3367-3379.
PMID: 33644786
Cell membranes interact with a myriad of curvature-active proteins that control membrane morphology and are responsible for mechanosensation and mechanotransduction. Some of these proteins, such as those containing BAR domains,...
8.
Le Roux A, Quiroga X, Walani N, Arroyo M, Roca-Cusachs P
Philos Trans R Soc Lond B Biol Sci
. 2019 Aug;
374(1779):20180221.
PMID: 31431176
Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical...
9.
Le Roux A, Mohammad I, Mateos B, Arbesu M, Gairi M, Khan F, et al.
iScience
. 2019 Jan;
12:194-203.
PMID: 30690395
The c-Src oncogene is anchored to the cytoplasmic membrane through its N-terminal myristoylated SH4 domain. This domain is part of an intramolecular fuzzy complex with the SH3 and Unique domains....
10.
Elosegui-Artola A, Andreu I, Beedle A, Lezamiz A, Uroz M, Kosmalska A, et al.
Cell
. 2017 Nov;
171(6):1397-1410.e14.
PMID: 29107331
YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we show that force applied to the nucleus directly drives YAP nuclear...