Pawan Malhotra
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Explore the profile of Pawan Malhotra including associated specialties, affiliations and a list of published articles.
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114
Citations
1737
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Recent Articles
11.
Machuki Onchieku N, Kumari S, Pandey R, Sharma V, Kumar M, Deshmukh A, et al.
Pathogens
. 2021 Nov;
10(11).
PMID: 34832620
Reduced sensitivity of the human malaria parasite, to Artemisinin and its derivatives (ARTs) threatens the global efforts towards eliminating malaria. ARTs have been shown to cause ubiquitous cellular and genetic...
12.
Saini E, Sheokand P, Sharma V, Agrawal P, Kaur I, Singh S, et al.
PLoS Pathog
. 2021 Jul;
17(7):e1009750.
PMID: 34324609
The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized...
13.
Shehzad S, Pandey R, Malhotra P, Gupta D
Molecules
. 2021 Jun;
26(9).
PMID: 34066964
The serine protease, DegP exhibits proteolytic and chaperone activities, essential for cellular protein quality control and normal cell development in eukaryotes. The DegP is essential for the parasite survival and...
14.
Pandey R, Gupta P, Mohmmed A, Malhotra P, Gupta D
FEBS Open Bio
. 2021 May;
11(7):1921-1929.
PMID: 33934569
Post-translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver (PfPRL)...
15.
Aratikatla E, Kalamuddin M, Rana K, Datta G, Asad M, Sundararaman S, et al.
Eur J Med Chem
. 2021 Apr;
220:113454.
PMID: 33901900
Artemisinin-based combination therapies (ACTs) have been able to reduce the clinical and pathological malaria cases in endemic areas around the globe. However, recent reports have shown a progressive decline in...
16.
Singh A, Kalamuddin M, Maqbool M, Mohmmed A, Malhotra P, Hoda N
Bioorg Chem
. 2020 Dec;
108:104514.
PMID: 33280833
Targeting Falcipain-2 (FP2) for the development of antimalarials is a promising and established concept in antimalarial drug discovery and development. FP2, a member of papain-family cysteine protease of the malaria...
17.
Aratikatla E, Kalamuddin M, Malhotra P, Mohmmed A, Bhattacharya A
ACS Omega
. 2020 Nov;
5(45):29025-29037.
PMID: 33225134
Racemic and enantioselective syntheses of γ-phenyl-γ-amino vinyl phosphonates and sulfones have been achieved using Horner-Wadsworth-Emmons olefination of trityl protected α-phenyl-α-amino aldehydes with tetraethyl methylenediphosphonate and diethyl ((phenylsulfonyl)methyl)phosphonate, respectively, without any...
18.
Phosphorylation of Rhoptry Protein RhopH3 Is Critical for Host Cell Invasion by the Malaria Parasite
Ekka R, Gupta A, Bhatnagar S, Malhotra P, Sharma P
mBio
. 2020 Oct;
11(5).
PMID: 33024030
Merozoites formed after asexual division of the malaria parasite invade the host red blood cells (RBCs), which is critical for initiating malaria infection. The process of invasion involves specialized organelles...
19.
Siddiqui M, Singh S, Malhotra P, Chitnis C
ACS Infect Dis
. 2020 Feb;
6(3):379-392.
PMID: 32003970
Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, . S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty...
20.
Rana D, Kalamuddin M, Sundriyal S, Jaiswal V, Sharma G, Das Sarma K, et al.
Bioorg Med Chem
. 2019 Nov;
28(1):115155.
PMID: 31744777
Falcipains (FPs), cysteine proteases in the malarial parasite, are emerging as the promising antimalarial drug targets. In order to identify novel FP inhibitors, we generated a pharmacophore derived from the...