Md Kalamuddin
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Explore the profile of Md Kalamuddin including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
127
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Recent Articles
1.
Jameel E, Madhav H, Agrawal P, Raza M, Ahmedi S, Rahman A, et al.
J Biomol Struct Dyn
. 2023 Mar;
41(24):15485-15506.
PMID: 36970842
Malaria still threatens half the globe population despite successful Artemisinin-based combination therapy. One of the reasons for our inability to eradicate malaria is the emergence of resistance to current antimalarials....
2.
Singh A, Kalamuddin M, Mohmmed A, Malhotra P, Hoda N
RSC Adv
. 2022 May;
9(67):39410-39421.
PMID: 35540629
Falcipain-2 (FP2) is a papain family cysteine protease and a key member of the hemoglobin degradation pathway, a process that is required at erythrocytic stages of to obtain amino acids....
3.
Aratikatla E, Kalamuddin M, Rana K, Datta G, Asad M, Sundararaman S, et al.
Eur J Med Chem
. 2021 Apr;
220:113454.
PMID: 33901900
Artemisinin-based combination therapies (ACTs) have been able to reduce the clinical and pathological malaria cases in endemic areas around the globe. However, recent reports have shown a progressive decline in...
4.
Singh A, Kalamuddin M, Maqbool M, Mohmmed A, Malhotra P, Hoda N
Bioorg Chem
. 2020 Dec;
108:104514.
PMID: 33280833
Targeting Falcipain-2 (FP2) for the development of antimalarials is a promising and established concept in antimalarial drug discovery and development. FP2, a member of papain-family cysteine protease of the malaria...
5.
Aratikatla E, Kalamuddin M, Malhotra P, Mohmmed A, Bhattacharya A
ACS Omega
. 2020 Nov;
5(45):29025-29037.
PMID: 33225134
Racemic and enantioselective syntheses of γ-phenyl-γ-amino vinyl phosphonates and sulfones have been achieved using Horner-Wadsworth-Emmons olefination of trityl protected α-phenyl-α-amino aldehydes with tetraethyl methylenediphosphonate and diethyl ((phenylsulfonyl)methyl)phosphonate, respectively, without any...
6.
Rana D, Kalamuddin M, Sundriyal S, Jaiswal V, Sharma G, Das Sarma K, et al.
Bioorg Med Chem
. 2019 Nov;
28(1):115155.
PMID: 31744777
Falcipains (FPs), cysteine proteases in the malarial parasite, are emerging as the promising antimalarial drug targets. In order to identify novel FP inhibitors, we generated a pharmacophore derived from the...
7.
Biochemical characterization of complement factors binding protein for its role in immune modulation
Sharma S, Kumar G, Vashishta M, Pandey R, Rathore S, Chourasia B, et al.
Biochem J
. 2018 Jul;
475(17):2877-2891.
PMID: 30049893
Complement system is the first line of human defence against intruding pathogens and is recognized as a potentially useful therapeutic target. Human malaria parasite employs a series of intricate mechanisms...
8.
Deshmukh A, Chourasia B, Mehrotra S, Kana I, Paul G, Panda A, et al.
Infect Immun
. 2018 May;
86(8).
PMID: 29760216
merozoite surface protein 3 (MSP3) is an abundantly expressed secreted merozoite surface protein and a leading malaria vaccine candidate antigen. However, it is unclear how MSP3 is retained on the...
9.
Paul G, Deshmukh A, Chourasia B, Kalamuddin M, Panda A, Singh S, et al.
Biochem J
. 2018 Mar;
475(6):1197-1209.
PMID: 29511044
merozoite surface protein (PfMSP) 1 has been studied extensively as a vaccine candidate antigen. PfMSP-1 undergoes proteolytic processing into four major products, such as p83, p30, p38, and p42, that...
10.
Prakash P, Zeeshan M, Saini E, Muneer A, Khurana S, Chourasia B, et al.
Nat Commun
. 2017 Nov;
8(1):1548.
PMID: 29146974
Invasion of human erythrocytes by Plasmodium falciparum merozoites involves multiple interactions between host receptors and their merozoite ligands. Here we report human Cyclophilin B as a receptor for PfRhopH3 during...