Pavel Martasek
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Explore the profile of Pavel Martasek including associated specialties, affiliations and a list of published articles.
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150
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Recent Articles
11.
Brogyanyi T, Kaplanek R, Kejik Z, Hosnedlova B, Antonyova V, Abramenko N, et al.
Biomed Pharmacother
. 2022 Sep;
155:113736.
PMID: 36156366
Dysregulation of iron homeostasis is one of the important processes in the development of many oncological diseases, such as pancreatic cancer. Targeting it with specific agents, such as an iron...
12.
Antonyova V, Tatar A, Brogyanyi T, Kejik Z, Kaplanek R, Vellieux F, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142763
Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated that...
13.
Leischner Fialova J, Honigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, et al.
Biomed Pharmacother
. 2022 Sep;
154:113582.
PMID: 36055111
Mitochondria generate energy and building blocks required for cellular growth and function. The notion that mitochondria are not involved in the cancer growth has been challenged in recent years together...
14.
Talianova V, Kejik Z, Kaplanek R, Vesela K, Abramenko N, Lacina L, et al.
Pharmaceutics
. 2022 Aug;
14(8).
PMID: 36015338
IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R) by small molecules is therefore an intensively...
15.
Kovarnik T, Hitoshi M, Kral A, Jerabek S, Zemanek D, Kawase Y, et al.
J Am Heart Assoc
. 2022 May;
11(9):e021490.
PMID: 35502771
Background The FiGARO (FFR versus iFR in Assessment of Hemodynamic Lesion Significance, and an Explanation of Their Discrepancies) trial is a prospective registry searching for predictors of fractional flow reserve/instantaneous...
16.
Novakova Z, Mikesova J, Ondrakova M, Kutil Z, Vesela K, Martasek P, et al.
Biochem Biophys Res Commun
. 2021 Dec;
588:182-186.
PMID: 34968794
Variegate porphyria is caused by mutations in the protoporphyrinogen oxidase IX (PPOX, EC 1.3.3.4) gene, resulting in reduced overall enzymatic activity of PPOX in human tissues. Recently, we have identified...
17.
Kejik Z, Kaplanek R, Dytrych P, Masarik M, Vesela K, Abramenko N, et al.
Pharmaceutics
. 2021 Nov;
13(11).
PMID: 34834295
Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in...
18.
Novakova Z, Khuntsaria D, Gresova M, Mikesova J, Havlinova B, Shukla S, et al.
PLoS One
. 2021 Nov;
16(11):e0259837.
PMID: 34793488
Human protoporphyrinogen oxidase IX (hPPO) is an oxygen-dependent enzyme catalyzing the penultimate step in the heme biosynthesis pathway. Mutations in the enzyme are linked to variegate porphyria, an autosomal dominant...
19.
Kejik Z, Kaplanek R, Masarik M, Babula P, Matkowski A, Filipensky P, et al.
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33440733
Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From...
20.
Leischner Fialova J, Raudenska M, Jakubek M, Kejik Z, Martasek P, Babula P, et al.
Mini Rev Med Chem
. 2020 Nov;
21(7):816-832.
PMID: 33213355
The search for mitochondria-targeted drugs has dramatically risen over the last decade. Mitochondria are essential organelles serving not only as a powerhouse of the cell but also as a key...