Paulo R R Costa
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Explore the profile of Paulo R R Costa including associated specialties, affiliations and a list of published articles.
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54
Citations
231
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Recent Articles
1.
Lapa D, Araujo L, Melo S, Costa P, Caleffi G
Molecules
. 2024 Jul;
29(14).
PMID: 39064997
The (,)-Teth-TsDPEN-Ru(II) complex promoted the one-pot double C=O reduction of α-alkyl-β-ketoaldehydes through asymmetric transfer hydrogenation/dynamic kinetic resolution (ATH-DKR) under mild conditions. In this process, ten -2-benzyl-1-phenylpropane-1,3-diols (85:15 to 92:8 dr)...
2.
Demidoff F, Costa P, Caleffi G
Org Biomol Chem
. 2024 May;
22(24):4839-4863.
PMID: 38819298
Rearranged homoisoflavonoids constitute a unique group of natural products, renowned for their structural diversity and complexity. These compounds, derived from modifications in the 3-benzylchroman skeleton, are categorized into four subclasses:...
3.
Thimoteo R, Neto P, Costa D, da Mota Ramalho Costa F, Brito D, Costa P, et al.
Mol Biol Rep
. 2024 Jan;
51(1):187.
PMID: 38270684
Background: Leukemias stand out for being the main type of childhood cancer in the world. Current treatments have strong side effects for patients, and there is still a high rate...
4.
Caleffi G, Rosa A, de Souza L, Avelar J, Nascimento S, de Almeida V, et al.
J Nat Prod
. 2023 May;
86(6):1536-1549.
PMID: 37257024
Aurones are a small subgroup of flavonoids in which the basic C-C-C skeleton is arranged as ()-2-benzylidenebenzofuran-3(2)-one. These compounds are structural isomers of flavones and flavonols, natural products reported as...
5.
Demidoff F, Caleffi G, Figueiredo M, Costa P
J Org Chem
. 2022 Oct;
87(21):14208-14222.
PMID: 36251770
The oxo-tethered-Ru(II) precatalyst promoted the one-pot C═C/C═O reduction of chalcones using sodium formate as the hydrogen source in water through asymmetric transfer hydrogenation. Twenty-seven 1,3-diarylpropan-1-ols were obtained in good to...
6.
Thimoteo R, Costa D, Martino T, Barcellos J, Coelho M, Costa P, et al.
Anticancer Res
. 2021 Oct;
41(10):4929-4936.
PMID: 34593440
Background/aim: A new set of LQB-nitrones and analogues was synthesized to evaluate anticancer activity based on the substitution of the terpenyl moiety of the antileukemic compound LQB-278 by the conformationally...
7.
Pacheco J, Costa D, Cunha-Junior E, Andrade-Neto V, Fairlamb A, Wyllie S, et al.
ACS Med Chem Lett
. 2021 Sep;
12(9):1405-1412.
PMID: 34531949
5-Nitro-furan nitrones () and 5-nitro-thiophene nitrones () were synthesized in one step. Compounds - had the most potent leishmanicidal activity against intracellular amastigote forms of and (from 0.019 to 2.76...
8.
Mendes J, Costa P, Yus M, Foubelo F, Buarque C
Beilstein J Org Chem
. 2021 Jun;
17:1096-1140.
PMID: 34093879
The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other compounds presenting different types of biological activities have proved to be successful employing chiral sulfinyl imines derived from -butanesulfinamide. These...
9.
Hancio T, Mazzoccoli L, Guimaraes G, Robaina M, Mendonca B, Nestal de Moraes G, et al.
Int J Oncol
. 2021 Mar;
58(6).
PMID: 33786613
Acute myeloid leukemia (AML) is a complex hematological disorder characterized by blockage of differentiation and high proliferation rates of myeloid progenitors. Anthracycline and cytarabine‑based therapy has remained the standard treatment...
10.
de Souza L, Salustiano E, da Costa K, Costa A, Rumjanek V, Domingos J, et al.
Bioorg Chem
. 2021 Mar;
110:104790.
PMID: 33743223
α-aryl-α-tetralones and α-fluoro-α-aryl-α-tetralones derivatives were synthesized by palladium catalyzed α-arylation reaction of α-tetralones and α-fluoro-α-tetralones, with bromoarenes in moderate to good yields. These compounds were evaluated for their in vitro...