Paulo Cesar Leal
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Explore the profile of Paulo Cesar Leal including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
453
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Recent Articles
11.
Andrade E, Forner S, Bento A, Leite D, Dias M, Leal P, et al.
Am J Physiol Renal Physiol
. 2011 Mar;
300(5):F1223-34.
PMID: 21367919
The ankyrin-repeat transient receptor potential 1 (TRPA1) has been implicated in pathological conditions of the bladder, but its role in overactive bladder (OAB) following spinal cord injury (SCI) remains unknown....
12.
Pereira Rangel L, Fritzen M, Yunes R, Leal P, Creczynski-Pasa T, Ferreira-Pereira A
FEMS Yeast Res
. 2010 Feb;
10(3):244-51.
PMID: 20132313
Overexpression of the Saccharomyces cerevisiae ABC transporter Pdr5p confers resistance to a range of structurally unrelated xenobiotics. This property allows Pdr5p to be used as a target for novel multidrug...
13.
da Costa D, Meotti F, Andrade E, Leal P, Motta E, Calixto J
Pain
. 2010 Jan;
148(3):431-437.
PMID: 20056530
This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar...
14.
Chaves J, Leal P, Pianowisky L, Calixto J
Planta Med
. 2008 Oct;
74(14):1678-83.
PMID: 18951339
A quantitative study was undertaken to assess the plasma and tissue levels, tissue distribution and skin (ear) absorption of the sesquiterpene alpha-humulene, the main active constituent isolated from the plant...
15.
Kratz J, Andrighetti-Frohner C, Kolling D, Leal P, Cesar Cirne-Santos C, Yunes R, et al.
Mem Inst Oswaldo Cruz
. 2008 Sep;
103(5):437-42.
PMID: 18797755
The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory...
16.
Bento A, Leite D, Claudino R, Hara D, Leal P, Calixto J
J Leukoc Biol
. 2008 Jul;
84(4):1213-21.
PMID: 18653784
Although neutrophils are strongly implicated in eliminating pathogens, excessive recruitment may cause tissue damage. Therefore, reducing cell influx during an inflammatory process may be a potential target for treating inflammatory...
17.
Kratz J, Andrighetti-Frohner C, Leal P, Nunes R, Yunes R, Trybala E, et al.
Biol Pharm Bull
. 2008 May;
31(5):903-7.
PMID: 18451516
The synthetic n-alkyl esters of gallic acid, also known as gallates, are widely employed as antioxidants by food and pharmaceutical industries. Besides the antioxidant activity, other biological activities have been...
18.
Alberton E, Damazio R, Cazarolli L, Chiaradia L, Leal P, Nunes R, et al.
Chem Biol Interact
. 2008 Jan;
171(3):355-62.
PMID: 18164698
A series of chalcone derivatives from 3,4-methylenedioxybenzaldehyde and substituted acetophenones have been synthesized and investigated as antihyperglycemic agents in a glucose loaded animal model. Chalcones with biological activity were compared...
19.
Chiaradia L, Dos Santos R, Vitor C, Vieira A, Leal P, Nunes R, et al.
Bioorg Med Chem
. 2007 Nov;
16(2):658-67.
PMID: 17988874
Inhibition of nitric oxide (NO) production by altering the expression of induced enzymes involved is potentially an important strategy for obtaining antiinflammatory agents. In the search for hits to obtain...
20.
Boeck P, Falcao C, Leal P, Yunes R, Filho V, Torres-Santos E, et al.
Bioorg Med Chem
. 2006 Jan;
14(5):1538-45.
PMID: 16386424
Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and some derivatives, and these analogues were tested for selective activity against both promastigotes and intracellular amastigotes of Leishmania...