Paulina H Wanrooij
Overview
Explore the profile of Paulina H Wanrooij including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
23
Citations
527
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Carvalho G, Nguyen T, Repoles B, Forslund J, Wijethunga W, Ranjbarian F, et al.
FEBS J
. 2025 Feb;
PMID: 39918244
AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis that also plays a role in preserving mitochondrial function and integrity. Upon a disturbance in the cellular energy...
2.
Aasumets K, Hangas A, Fragkoulis G, Bader C, Erdinc D, Wanrooij S, et al.
Mol Biol Cell
. 2024 Dec;
36(2):ar11.
PMID: 39705374
Mirin, a chemical inhibitor of MRE11, has been recently reported to suppress immune response triggered by mitochondrial DNA (mtDNA) breakage and release during replication stalling. We show that while Mirin...
3.
PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs
Breidenstein A, Lamy A, Bader C, Sun W, Wanrooij P, Berntsson R
Life Sci Alliance
. 2024 May;
7(8).
PMID: 38811160
A major pathway for horizontal gene transfer is the transmission of DNA from donor to recipient cells via plasmid-encoded type IV secretion systems (T4SSs). Many conjugative plasmids encode for a...
4.
Gorospe C, Carvalho G, Herrera Curbelo A, Marchhart L, Mendes I, Niedzwiecka K, et al.
Life Sci Alliance
. 2023 Sep;
6(12).
PMID: 37696576
Mitochondria are central to numerous metabolic pathways whereby mitochondrial dysfunction has a profound impact and can manifest in disease. The consequences of mitochondrial dysfunction can be ameliorated by adaptive responses...
5.
Wanrooij P, Chabes A
EMBO J
. 2023 Aug;
42(18):e114990.
PMID: 37548337
The building blocks for RNA and DNA are made in the cytosol, meaning mitochondria depend on the import and salvage of ribonucleoside triphosphates (rNTPs) and deoxyribonucleoside triphosphates (dNTPs) for the...
6.
Gorospe C, Repoles B, Wanrooij P
Methods Mol Biol
. 2023 Feb;
2615:293-314.
PMID: 36807800
Impaired mitochondrial DNA (mtDNA) maintenance, due to, e.g., defects in the replication machinery or an insufficient dNTP supply, underlies a number of mitochondrial disorders. The normal process of mtDNA replication...
7.
Repoles B, Gorospe C, Tran P, Nilsson A, Wanrooij P
Mitochondrion
. 2021 Nov;
61:179-187.
PMID: 34728429
The integrity of mitochondrial DNA (mtDNA) isolated from solid tissues is critical for analyses such as long-range PCR, but is typically assessed under conditions that fail to provide information on...
8.
Carvalho G, Repoles B, Mendes I, Wanrooij P
Antioxid Redox Signal
. 2021 May;
36(13-15):885-905.
PMID: 34015960
The small, multicopy mitochondrial genome (mitochondrial DNA [mtDNA]) is essential for efficient energy production, as alterations in its coding information or a decrease in its copy number disrupt mitochondrial ATP...
9.
Wanrooij P, Tran P, Thompson L, Carvalho G, Sharma S, Kreisel K, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(25):14306-14313.
PMID: 32513727
Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat to genome stability and can result in DNA strand breaks when not removed in a timely manner. However, the...
10.
Tran P, Wanrooij P, Lorenzon P, Sharma S, Thelander L, Nilsson A, et al.
J Biol Chem
. 2019 Jul;
294(44):15889-15897.
PMID: 31300555
The building blocks of DNA, dNTPs, can be produced or can be salvaged from deoxyribonucleosides. However, to what extent the absence of dNTP production can be compensated for by the...