Paula M Cannon
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Explore the profile of Paula M Cannon including associated specialties, affiliations and a list of published articles.
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55
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2140
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Recent Articles
1.
Rogers G, Huang C, Mathur A, Huang X, Chen H, Stanten K, et al.
Nat Biomed Eng
. 2024 Jul;
8(12):1700-1714.
PMID: 39039240
The immunoglobulin locus of B cells can be reprogrammed by genome editing to produce custom or non-natural antibodies that are not induced by immunization. However, current strategies for antibody reprogramming...
2.
Llewellyn G, Chen H, Rogers G, Huang X, Sell P, Henley J, et al.
J Virol
. 2023 Aug;
97(8):e0068423.
PMID: 37555663
With increasing resistance of SARS-CoV-2 variants to antibodies, there is interest in developing entry inhibitors that target essential receptor-binding regions of the viral Spike protein and thereby present a high...
3.
Rogers G, Huang C, Mathur A, Huang X, Chen H, Stanten K, et al.
Res Sq
. 2023 Jul;
PMID: 37503066
We describe a genome editing strategy to reprogram the immunoglobulin heavy chain (IgH) locus of human B cells to express custom molecules that respond to immunization. These heavy chain antibodies...
4.
Rogers G, Huang C, Mathur A, Huang X, Chen H, Stanten K, et al.
bioRxiv
. 2023 Jul;
PMID: 37425794
We describe a genome editing strategy to reprogram the immunoglobulin heavy chain (IgH) locus of human B cells to express custom molecules that respond to immunization. These heavy chain antibodies...
5.
Li L, Sottas C, Chen H, Li Y, Cui H, Villano J, et al.
Cells
. 2023 May;
12(8).
PMID: 37190107
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a SARS-like coronavirus, continues to produce mounting infections and fatalities all over the world. Recent data point to SARS-CoV-2 viral infections in the...
6.
Lundquist A, Llewellyn G, Kishi S, Jakowec N, Cannon P, Petzinger G, et al.
Mol Neurobiol
. 2021 Nov;
59(2):1002-1017.
PMID: 34822124
Monocarboxylate transporters (MCTs) shuttle molecules, including L-lactate, involved in metabolism and cell signaling of the central nervous system. Astrocyte-specific MCT4 is a key component of the astrocyte-neuron lactate shuttle (ANLS)...
7.
Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes
Rogers G, Huang C, Clark R, Seclen E, Chen H, Cannon P
Mol Ther Methods Clin Dev
. 2021 Oct;
23:198-209.
PMID: 34703842
Adeno-associated virus serotype 6 (AAV6) is a valuable reagent for genome editing of hematopoietic cells due to its ability to serve as a homology donor template. However, a comprehensive study...
8.
9.
Rogers G, Cannon P
Mol Ther
. 2021 Sep;
29(11):3192-3204.
PMID: 34563675
Cell therapies based on reprogrammed adaptive immune cells have great potential as "living drugs." As first demonstrated clinically for engineered chimeric antigen receptor (CAR) T cells, the ability of such...
10.
Chen H, Huang C, Tian L, Huang X, Zhang C, Llewellyn G, et al.
J Virol
. 2021 Sep;
95(22):e0096621.
PMID: 34495700
The high pathogenicity of SARS-CoV-2 requires it to be handled under biosafety level 3 conditions. Consequently, Spike protein-pseudotyped vectors are a useful tool to study viral entry and its inhibition,...