Colin M Exline
Overview
Explore the profile of Colin M Exline including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
587
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Recent Articles
1.
Wang J, Exline C, DeClercq J, Llewellyn G, Hayward S, Li P, et al.
Nat Biotechnol
. 2015 Nov;
33(12):1256-1263.
PMID: 26551060
Genome editing with targeted nucleases and DNA donor templates homologous to the break site has proven challenging in human hematopoietic stem and progenitor cells (HSPCs), and particularly in the most...
2.
Exline C, Yang S, Haworth K, Rengarajan S, Lopez L, Droniou M, et al.
Retrovirology
. 2015 Aug;
12:67.
PMID: 26248668
Background: The interferon-inducible factor BST-2/tetherin blocks the release of nascent virions from the surface of infected cells for certain enveloped virus families. The primate lentiviruses have evolved several counteracting mechanisms...
3.
Rathbun J, Droniou M, Damoiseaux R, Haworth K, Henley J, Exline C, et al.
J Virol
. 2015 Jun;
89(16):8428-43.
PMID: 26041296
Unlabelled: Certain members of the Arenaviridae family are category A agents capable of causing severe hemorrhagic fevers in humans. Specific antiviral treatments do not exist, and the only commonly used...
4.
Hofer U, Henley J, Exline C, Mulhern O, Lopez E, Cannon P
J Infect Dis
. 2013 Oct;
208 Suppl 2:S160-4.
PMID: 24151324
Genetic strategies to block expression of CCR5, the major co-receptor of human immunodeficiency virus type 1 (HIV-1), are being developed as anti-HIV therapies. For example, human hematopoietic stem/precursor cells (HSPC)...
5.
Lopez L, Yang S, Exline C, Rengarajan S, Haworth K, Cannon P
J Virol
. 2012 Mar;
86(10):5467-80.
PMID: 22398279
BST-2/tetherin is an interferon-inducible host restriction factor that blocks the release of newly formed enveloped viruses. It is enriched in lipid raft membrane microdomains, which are also the sites of...
6.
Droniou-Bonzom M, Reignier T, Oldenburg J, Cox A, Exline C, Rathbun J, et al.
J Virol
. 2011 Oct;
85(24):13457-62.
PMID: 21976641
Candid#1 (Cd1) is an attenuated vaccine strain of Junin virus, the causative agent of Argentine hemorrhagic fever. Although several substitutions are present in Cd1, their importance for attenuation has not...
7.
Yang S, Lopez L, Exline C, Haworth K, Cannon P
Retrovirology
. 2011 Sep;
8:78.
PMID: 21955466
Background: HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite the same genomic organization, only the group M viruses are responsible for the world-wide pandemic...
8.
Hauser H, Lopez L, Yang S, Oldenburg J, Exline C, Guatelli J, et al.
Retrovirology
. 2010 Jun;
7:51.
PMID: 20529266
Background: In the absence of the Vpu protein, newly formed HIV-1 particles can remain attached to the surface of human cells due to the action of an interferon-inducible cellular restriction...
9.
Lopez L, Yang S, Hauser H, Exline C, Haworth K, Oldenburg J, et al.
J Virol
. 2010 May;
84(14):7243-55.
PMID: 20444895
BST-2/tetherin is an interferon-inducible protein that restricts the release of enveloped viruses from the surface of infected cells by physically linking viral and cellular membranes. It is present at both...
10.
Yang S, Lopez L, Hauser H, Exline C, Haworth K, Cannon P
Retrovirology
. 2010 Feb;
7:13.
PMID: 20167081
Background: The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells. However,...