Paula M Cannon
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Explore the profile of Paula M Cannon including associated specialties, affiliations and a list of published articles.
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55
Citations
2140
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Recent Articles
11.
Tatiossian K, Clark R, Huang C, Thornton M, Grubbs B, Cannon P
Mol Ther
. 2020 Nov;
29(3):1057-1069.
PMID: 33160457
Homology-directed repair (HDR) of a DNA break allows copying of genetic material from an exogenous DNA template and is frequently exploited in CRISPR-Cas9 genome editing. However, HDR is in competition...
12.
Hope T, Klatt N, Sacha J, Cannon P
AIDS Res Hum Retroviruses
. 2020 Oct;
36(11):883-885.
PMID: 33050710
No abstract available.
13.
Cannon P
Cell Stem Cell
. 2019 Dec;
25(6):735-736.
PMID: 31809736
Cell therapy efforts for treating HIV+ patients are challenged by limited availability of donors with naturally occurring CCR5 mutations conferring resistance. Xu et al. (2019) report a CRISPR-based method for...
14.
Rogers G, Chen H, Morales H, Cannon P
Mol Ther
. 2019 Nov;
27(12):2061-2062.
PMID: 31735602
No abstract available.
15.
Rogers G, Chen H, Morales H, Cannon P
Mol Ther
. 2019 Sep;
27(10):1726-1736.
PMID: 31540849
Adeno-associated virus (AAV) vectors are frequently used as donor templates for genome editing by homologous recombination. Although modification rates are typically under 1%, they are greatly enhanced by targeted double-stranded...
16.
Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 and TIGIT CD4 T Cells
Llewellyn G, Seclen E, Wietgrefe S, Liu S, Chateau M, Pei H, et al.
J Virol
. 2019 Mar;
93(10).
PMID: 30842333
Combination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but does not result in virus eradication or a cure. A major contributing factor is the long-term persistence of a reservoir...
17.
Llewellyn G, Alvarez-Carbonell D, Chateau M, Karn J, Cannon P
J Neurovirol
. 2017 Dec;
24(2):192-203.
PMID: 29256041
Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages,...
18.
Canny M, Moatti N, Wan L, Fradet-Turcotte A, Krasner D, Mateos-Gomez P, et al.
Nat Biotechnol
. 2017 Nov;
36(1):95-102.
PMID: 29176614
Programmable nucleases, such as Cas9, are used for precise genome editing by homology-dependent repair (HDR). However, HDR efficiency is constrained by competition from other double-strand break (DSB) repair pathways, including...
19.
Rogers G, Cannon P
Hematol Oncol Clin North Am
. 2017 Sep;
31(5):883-895.
PMID: 28895854
Advances in gene therapy technologies, particularly in gene editing, are suggesting new avenues for the treatment of human immunodeficiency virus and other infectious diseases. This article outlines recent developments in...
20.
Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra A, Gassa A, et al.
Nat Commun
. 2017 Mar;
8:14447.
PMID: 28248314
Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity. New therapeutic approaches that induce a strong and prolonged immune...