Paul V Murphy
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Explore the profile of Paul V Murphy including associated specialties, affiliations and a list of published articles.
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101
Citations
680
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Recent Articles
1.
Hever E, Santhanam V, Alberi S, Dhara A, Bols M, Nasheuer H, et al.
Org Biomol Chem
. 2024 Aug;
22(36):7460-7477.
PMID: 39189157
Isopropyl 1-thio-β-D-galactopyranoside (IPTG, 1) is used widely as an inducer of protein expression in and 1-β-D-galactopyranosyl-2-methylpropane (2), a -glycoside analogue of 1, has also been identified as an inducer. Here,...
2.
Murphy P, Dhara A, Fitzgerald L, Hever E, Konda S, Mandal K
Chem Soc Rev
. 2024 Aug;
53(19):9428-9445.
PMID: 39162695
Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin-ligand interactions and show how these molecular recognition events inspire innovations such as: (i) glycomimetic ligands;...
3.
Bennett J, Murphy P
Org Process Res Dev
. 2024 May;
28(5):1848-1859.
PMID: 38783857
C-Glycosyl compounds (C-glycosides) are a class of saccharide derivatives with improved stability over their O-linked counterparts. This paper reports the synthesis of several -2-(C-glycosyl)acetates via a tandem Wittig-Michael reaction from...
4.
Alaa Eldin Refat L, Karpinska J, Konda S, Simmie J, Murphy P, McArdle P, et al.
Chemistry
. 2024 Apr;
30(36):e202400672.
PMID: 38623589
The solvent-free elimination of sulfinic acid and aromatization of 1,6-trans-substituted bis(arylsulfone) trienes is reported. It is shown that sublimation can be used as a 'green' method to combine the thermal...
5.
Gabba A, Murphy P, Kiessling L, Birrane G
Biochemistry
. 2024 Jan;
63(2):191-193.
PMID: 38165812
No abstract available.
6.
Gabba A, Attariya R, Behren S, Pett C, van der Horst J, Yurugi H, et al.
J Am Chem Soc
. 2023 Jun;
145(24):13027-13037.
PMID: 37279388
Mucin expression and glycosylation patterns on cancer cells differ markedly from healthy cells. Mucin 1 (MUC1) is overexpressed in several solid tumors and presents high levels of aberrant, truncated O-glycans...
7.
Bennett J, Murphy P
Carbohydr Res
. 2023 May;
529:108845.
PMID: 37210941
1-Deoxynojirimycin (1-DNJ) is a glycoprocessing inhibitor, and it serves as a synthetic precursor to two of three currently marketed iminosugar drugs, miglustat (N-butyl DNJ/Zavesca®) and miglitol (Glyset®). Herein a continuous...
8.
Manning J, Baldoneschi V, Romero-Hernandez L, Pichler K, Caballero G, Andre S, et al.
Bioorg Med Chem
. 2022 Nov;
75:117068.
PMID: 36327696
Pairing glycans with tissue lectins controls multiple effector pathways in (patho)physiology. A clinically relevant example is the prodegradative activity of galectins-1 and -3 (Gal-1 and -3) in the progression of...
9.
Roy A, Byrne S, Sarangi N, Murphy P, Keyes T
Front Mol Biosci
. 2022 Oct;
9:1017338.
PMID: 36310596
Seasonal periodic pandemics and epidemics caused by Influenza A viruses (IAVs) are associated with high morbidity and mortality worldwide. They are frequent and unpredictable in severity so there is a...
10.
Dhara D, Dhara A, Murphy P, Mulard L
Carbohydr Res
. 2022 Aug;
521:108644.
PMID: 36030632
Chemical synthesis is a powerful tool to access homogeneous complex glycans, which relies on protecting group (PG) chemistry. However, the overall efficiency of chemical glycan assembly is still low when...