Organic Process Research & Development
Overview
Organic Process Research & Development is a peer-reviewed scientific journal that focuses on the development and optimization of organic chemical processes. It covers a wide range of topics including reaction design, catalyst development, process scale-up, and green chemistry. The journal provides a platform for researchers and industrial practitioners to share their innovative approaches and advancements in the field of organic process research and development.
Details
Details
Abbr.
Org Process Res Dev
Publisher
American Chemical Society
Start
1997
End
Continuing
Frequency
Bimonthly
p-ISSN
1083-6160
e-ISSN
1520-586X
Country
United States
Language
English
Metrics
Metrics
h-index / Ranks: 2024
127
SJR / Ranks: 4485
900
CiteScore / Ranks: 3323
6.50
JIF / Ranks: 2884
3.4
Recent Articles
1.
Chaudhuri A, de Groot W, Schuurmans J, Zondag S, Bianchi A, Kuijpers K, et al.
Org Process Res Dev
. 2025 Feb;
29(2):460-471.
PMID: 40012916
Photochemical transformations have garnered renewed interest over the past decade for their ability to enable unique reactions under mild conditions. However, scaling up such processes, particularly in multiphase systems (e.g.,...
2.
Takle M, Schrecker L, Deadman B, Dickhaut J, Wieja A, Hellgardt K, et al.
Org Process Res Dev
. 2025 Feb;
29(2):545-554.
PMID: 40012915
The robustness of the flash thermal racemization of optically active 1-phenylethylamine over Pd/γ-AlO was studied by applying split-plot design-of-experiments (DoE), where the effects of temperature, flow rate, and concentration (3-factors)...
3.
Trunov D, Izovsky J, Beranek J, Dammer O, Soos M
Org Process Res Dev
. 2025 Jan;
29(1):56-65.
PMID: 39839540
The choice of method for drug amorphization depends on various factors, including the physicochemical properties of the active pharmaceutical ingredients, the desired formulation, and scalability requirements. It is often important...
4.
Teixeira R, Waldron Clarke T, Love A, Sun X, Kayal S, George M
Org Process Res Dev
. 2025 Jan;
29(1):34-47.
PMID: 39839539
We report the development and optimization of a scalable flow process for metallaphotoredox (Ir/Ni) C-O coupling, a mild and efficient approach for forming alkyl-aryl ethers, a common motif in medicinal...
5.
Villena M, Doorenbos Z, Sullivan K, Brettmann B
Org Process Res Dev
. 2024 Dec;
28(12):4338-4347.
PMID: 39723332
Control of powder properties is crucial for industrial processes across the food, pharmaceutical, agriculture, and mineral processing industries, and granulation is an important tool for providing agglomerated particles with controllable...
6.
Zhang B, Stefanidis G, Van Gerven T
Org Process Res Dev
. 2024 Dec;
28(12):4431-4443.
PMID: 39723331
Continuous crystallization has gained substantial interest due to its high product reproducibility, high labor efficiency, and low capital and production costs. Continuous seeding is preferable and often even required in...
7.
Ryu U, Ly D, Shimabukuro K, Davies H, Jones C
Org Process Res Dev
. 2024 Nov;
28(11):4146-4155.
PMID: 39569052
A catalyst-in-bag system facilitates the recovery and recycling of chiral dirhodium carboxylate catalysts used for enantioselective, intermolecular cyclopropanation. The catalyst-in-bag system incorporates a soluble enantioselective dirhodium complex catalyst within a...
8.
Chakraborty A, Soltanzadeh B, Wills N, Jaganathan A, Borhan B
Org Process Res Dev
. 2024 Nov;
28(11):3959-3962.
PMID: 39569051
This report presents a rapid, ecofriendly technique for the formation of commonly used -bromo and -iodinating reagents by reacting readily available -chloro derivatives with inorganic bromide and iodide salts. All...
9.
Vanluchene A, Horsten T, Bonneure E, Stevens C
Org Process Res Dev
. 2024 Nov;
28(11):4018-4023.
PMID: 39569050
The development of sustainable trifluoromethylations of enamides is of great interest to the pharmaceutical industry. Herein, we demonstrate a sustainable direct electrochemical trifluoromethylation method in a microflow cell, using Langlois...
10.
Hodgin G, Burns M, Deadman B, Roberts C, Mimi Hii K, Nguyen B
Org Process Res Dev
. 2024 Oct;
28(10):3837-3846.
PMID: 39444428
The knowledge of the reactivity of -nitrosamines (NSAs) with common organic reagents in synthesis is essential in determining their presence in pharmaceutical products, if formed and retained during synthesis. In...