Joshua L Schipper
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Explore the profile of Joshua L Schipper including associated specialties, affiliations and a list of published articles.
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10
Citations
210
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Recent Articles
1.
Grit J, McGee L, Tovar E, Essenburg C, Wolfrum E, Beddows I, et al.
Oncogene
. 2024 Mar;
43(19):1411-1430.
PMID: 38480916
Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell...
2.
Shen N, Zhao J, Schipper J, Zhang Y, Bepler T, Leehr D, et al.
Cell Syst
. 2018 Apr;
6(4):470-483.e8.
PMID: 29605182
Paralogous transcription factors (TFs) are oftentimes reported to have identical DNA-binding motifs, despite the fact that they perform distinct regulatory functions. Differential genomic targeting by paralogous TFs is generally assumed...
3.
Merrill N, Schipper J, Karnes J, Kauffman A, Martin K, MacKeigan J
PLoS One
. 2017 Sep;
12(9):e0184909.
PMID: 28910396
Phosphoinositide 3-kinase (PI3K) family members are involved in diverse cellular fates including cell growth, proliferation, and survival. While many molecular details are known about the Class I and III PI3Ks,...
4.
Schipper J, Gordan R
Cold Spring Harb Protoc
. 2016 Nov;
2016(11).
PMID: 27803259
The DNA binding specificity of transcription factors (TFs) is typically represented in the form of a position weight matrix (PWM), also known as a DNA motif. A PWM is a...
5.
Maciag J, Mackenzie S, Tucker M, Schipper J, Swartz P, Clark A
Proc Natl Acad Sci U S A
. 2016 Sep;
113(41):E6080-E6088.
PMID: 27681633
The native ensemble of caspases is described globally by a complex energy landscape where the binding of substrate selects for the active conformation, whereas targeting an allosteric site in the...
6.
Afek A, Schipper J, Horton J, Gordan R, Lukatsky D
Proc Natl Acad Sci U S A
. 2014 Oct;
111(48):17140-5.
PMID: 25313048
Until now, it has been reasonably assumed that specific base-pair recognition is the only mechanism controlling the specificity of transcription factor (TF)-DNA binding. Contrary to this assumption, here we show...
7.
Mackenzie S, Schipper J, England E, Thomas 3rd M, Blackburn K, Swartz P, et al.
Biochemistry
. 2013 Aug;
52(36):6219-31.
PMID: 23941397
The conformational ensemble of procaspase 3, the primary executioner in apoptosis, contains two major forms, inactive and active, with the inactive state favored in the native ensemble. A region of...
8.
Walters J, Schipper J, Swartz P, Mattos C, Clark A
Biosci Rep
. 2012 May;
32(4):401-11.
PMID: 22607239
A mutation in the allosteric site of the caspase 3 dimer interface of Val266 to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action...
9.
Schipper J, Mackenzie S, Sharma A, Clark A
Biophys Chem
. 2011 Jun;
159(1):100-9.
PMID: 21645959
The dimer interface of caspase-3 contains a bifunctional allosteric site in which the enzyme can be activated or inactivated, depending on the context of the protein. In the mature caspase-3,...
10.
Mackenzie S, Schipper J, Clark A
Curr Opin Drug Discov Devel
. 2010 Sep;
13(5):568-76.
PMID: 20812148
Caspases are a family of proteases that are involved in the execution of apoptosis and the inflammatory response. A plethora of diseases occur as a result of the dysregulation of...