Paul R Thompson
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Explore the profile of Paul R Thompson including associated specialties, affiliations and a list of published articles.
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185
Citations
8263
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Recent Articles
11.
Zhu Y, Speir M, Tan Z, Lee J, Nowell C, Chen A, et al.
Sci Adv
. 2023 Dec;
9(51):eadj1397.
PMID: 38117877
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase...
12.
Geary B, Sun B, Tilvawala R, Barasa L, Tsoyi K, Rosas I, et al.
Front Immunol
. 2023 Dec;
14:1290585.
PMID: 38094295
Introduction: MZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells show that it interacts with...
13.
Pasquero S, Gugliesi F, Biolatti M, DellOste V, Albano C, Bajetto G, et al.
PLoS Pathog
. 2023 Dec;
19(12):e1011849.
PMID: 38055760
Herpes simplex virus 1 (HSV-1) is a neurotropic virus that remains latent in neuronal cell bodies but reactivates throughout an individual's life, causing severe adverse reactions, such as herpes simplex...
14.
Xue T, Fei S, Gu J, Li N, Zhang P, Liu X, et al.
Philos Trans R Soc Lond B Biol Sci
. 2023 Oct;
378(1890):20220246.
PMID: 37778380
Drug resistance is still a big challenge for cancer patients. We previously demonstrated that inhibiting peptidylarginine deiminase 2 (PADI2) enzyme activity with Cl-amine increases the efficacy of docetaxel (Doc) on...
15.
Barasa L, Thompson P
Philos Trans R Soc Lond B Biol Sci
. 2023 Oct;
378(1890):20220240.
PMID: 37778377
Protein citrullination is a post-translational modification (PTM) that is catalysed by the protein arginine deiminase (PAD) family of enzymes. This PTM involves the transformation of an arginine residue into citrulline....
16.
Barasa L, Chaudhuri S, Zhou J, Jiang Z, Choudhary S, Green R, et al.
J Am Chem Soc
. 2023 Sep;
145(37):20273-20288.
PMID: 37695732
The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust inflammatory response. While...
17.
Humphries F, Shmuel-Galia L, Jiang Z, Zhou J, Barasa L, Mondal S, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2305420120.
PMID: 37549268
Stimulator of interferon genes (STING) is an essential adaptor protein required for the inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which binds and activates STING triggering...
18.
Ralston B, Khan L, DeVore S, Bronnenberg T, Flock J, Sequoia A, et al.
Reproduction
. 2023 Jun;
166(2):125-134.
PMID: 37310889
In Brief: DGCR8 microprocessor complex, which is important for miRNA biogenesis, is regulated by peptidylarginine deiminase 2 and expression fluctuates in gonadotrope cells across the mouse estrous cycle. Abstract: Canonical...
19.
Icso J, Barasa L, Thompson P
Biochemistry
. 2023 Jun;
62(13):2065-2078.
PMID: 37307562
Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1 (SARM1) is an NAD hydrolase and cyclase involved in axonal degeneration. In addition to NAD hydrolysis and cyclization, SARM1 catalyzes...
20.
Green R, Thompson P
Curr Opin Chem Biol
. 2023 May;
75:102313.
PMID: 37148643
Protein citrullination is a post-translational modification of arginine that controls a diverse array of cellular processes, including gene regulation, protein stability, and neutrophil extracellular trap (NET) formation. Histone citrullination promotes...