Aaron Muth
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Explore the profile of Aaron Muth including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
1304
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Recent Articles
1.
Chavan T, Kanabar D, Patel K, Laflamme T, Riyazi M, Spratt D, et al.
Bioorg Med Chem
. 2024 Jul;
110:117836.
PMID: 39029437
Liver cancer is a complex disease that involves various oncoproteins and the inactivation of tumor suppressor proteins (TSPs). Gankyrin is one such oncoprotein, first identified in human hepatocellular carcinoma, that...
2.
Kanabar D, Kane E, Chavan T, Laflamme T, Suarez E, Goyal M, et al.
Future Med Chem
. 2024 Jan;
16(3):239-251.
PMID: 38205637
Gankyrin is an ankyrin-repeat protein that promotes cell proliferation, tumor development and cancer progression when overexpressed. To design and synthesize a novel series of gankyrin-binding small molecules predicated on a...
3.
Wang X, Chauhan G, Tacderas A, Muth A, Gupta V
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982279
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer affecting the pleural lining of the lungs. Celastrol (Cela), a pentacyclic triterpenoid, has demonstrated promising therapeutic potential as an antioxidant,...
4.
Patil S, Barji D, Chavan T, Patel K, Collazo A, Prithipaul V, et al.
AAPS PharmSciTech
. 2023 Jan;
24(1):49.
PMID: 36702977
Tuberculosis (TB) is a contiguous airborne disease caused by Mycobacterium tuberculosis (M.tb), primarily affecting the human lungs. The progression of drug-susceptible TB to drug-resistant strains, MDR-TB and XDR-TB, has become...
5.
Yadav A, Alnakhli A, Vemana H, Bhutkar S, Muth A, Dukhande V
Pharm Res
. 2022 Oct;
39(11):2871-2883.
PMID: 36195821
Purpose: Glioblastoma multiforme (GBM) is a grade IV, highly proliferative, and malignant form of brain tumor with a 5-year survival rate at ~ 5%. Current treatment strategies for GBM include...
6.
DSouza A, Gnanamony M, Thomas M, Hanley P, Kanabar D, de Alarcon P, et al.
Cancers (Basel)
. 2022 Jul;
14(13).
PMID: 35804840
Background: Gankyrin, a member of the 26S proteasome, is an overexpressed oncoprotein in hepatoblastoma (HBL) and hepatocellular carcinoma (HCC). Cjoc42 was the first small molecule inhibitor of Gankyrin developed; however,...
7.
Kanabar D, Goyal M, Kane E, Chavan T, Kabir A, Wang X, et al.
J Med Chem
. 2022 Jun;
65(13):8975-8997.
PMID: 35758870
Gankyrin is an oncoprotein responsible for the development of numerous cancer types. It regulates the expression levels of multiple tumor suppressor proteins (TSPs) in liver cancer; however, gankyrin's regulation of...
8.
Kabir A, Muth A
Pharmacol Res
. 2022 Jan;
176:106055.
PMID: 34990865
Polypharmacology is a concept where a molecule can interact with two or more targets simultaneously. It offers many advantages as compared to the conventional single-targeting molecules. A multi-targeting drug is...
9.
Chilamakuri R, Rouse D, Yu Y, Kabir A, Muth A, Yang J, et al.
Transl Oncol
. 2021 Nov;
15(1):101272.
PMID: 34823094
High-risk neuroblastoma (NB) represents a major clinical challenge in pediatric oncology due to relapse of metastatic, drug-resistant disease, and treatment-related toxicities. An analysis of 1235 primary NB patient dataset revealed...
10.
Shukla S, Sarode A, Kanabar D, Muth A, Kunda N, Mitragotri S, et al.
Mater Sci Eng C Mater Biol Appl
. 2021 Sep;
128:112324.
PMID: 34474875
Pulmonary drug delivery is governed by several biophysical parameters of delivery carriers, such as particle size, shape, density, charge, and surface modifications. Although much attention has been given to other...