Paul P Geurink
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Explore the profile of Paul P Geurink including associated specialties, affiliations and a list of published articles.
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59
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2550
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Recent Articles
1.
Roberts C, Kaur S, Ogden A, Divine M, Warren G, Kang D, et al.
bioRxiv
. 2024 Sep;
PMID: 39345563
Ubiquitin signaling controls many aspects of eukaryotic biology, including targeted protein degradation and immune defense. Remarkably, invading bacterial pathogens have adapted secreted effector proteins that hijack host ubiquitination to gain...
2.
Szczesna M, Huang Y, Lacoursiere R, Bonini F, Pol V, Koc F, et al.
Cell Host Microbe
. 2024 Jun;
32(6):913-924.e7.
PMID: 38870903
Aspects of how Burkholderia escape the host's intrinsic immune response to replicate in the cell cytosol remain enigmatic. Here, we show that Burkholderia has evolved two mechanisms to block the...
3.
Jia Y, Oyken M, Kim R, Tjokrodirijo R, de Ru A, Janssen A, et al.
J Med Chem
. 2024 May;
67(10):7935-7953.
PMID: 38713163
The integration of diverse chemical tools like small-molecule inhibitors, activity-based probes (ABPs), and proteolysis targeting chimeras (PROTACs) advances clinical drug discovery and facilitates the exploration of various biological facets of...
4.
van Huizen M, Bloeme-Ter Horst J, de Gruyter H, Geurink P, van der Heden van Noort G, Knaap R, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1012100.
PMID: 38527094
The coronavirus papain-like protease (PLpro) is crucial for viral replicase polyprotein processing. Additionally, PLpro can subvert host defense mechanisms by its deubiquitinating (DUB) and deISGylating activities. To elucidate the role...
5.
Gan J, Pinto-Fernandez A, Flierman D, Akkermans J, OBrien D, Greenwood H, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(50):e2315163120.
PMID: 38055744
Interferon-induced ubiquitin (Ub)-like modifier ISG15 covalently modifies host and viral proteins to restrict viral infections. Its function is counteracted by the canonical deISGylase USP18 or Ub-specific protease 18. Notwithstanding indications...
6.
Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication
Herzog A, Gobel K, Marongiu L, Ruetalo N, Campos Alonso M, Leischner C, et al.
Phytomedicine
. 2023 Nov;
123:155176.
PMID: 37976697
Background: Selected natural compounds exhibit very good antiviral properties. Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant metabolites some of which have previously shown antiviral activities. Among...
7.
van der Gracht D, Rowland R, Roig-Zamboni V, Ferraz M, Louwerse M, Geurink P, et al.
Chem Sci
. 2023 Sep;
14(34):9136-9144.
PMID: 37655021
Lysosomal exoglycosidases are responsible for processing endocytosed glycans from the non-reducing end to produce the corresponding monosaccharides. Genetic mutations in a particular lysosomal glycosidase may result in accumulation of its...
8.
Gan J, de Vries J, Akkermans J, Mohammed Y, Tjokrodirijo R, de Ru A, et al.
ACS Chem Biol
. 2023 Aug;
18(9):2003-2013.
PMID: 37642399
Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is often overexpressed during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be...
9.
Szczesna M, Huang Y, Lacoursiere R, Bonini F, Pol V, Koc F, et al.
Res Sq
. 2023 Jul;
PMID: 37503018
Pathogenic bacteria have evolved diverse mechanisms to counteract cell-autonomous immunity, which otherwise guards both immune and non-immune cells from the onset of an infection. The versatile immunity protein Ring finger...
10.
Perez Berrocal D, Vishwanatha T, Horn-Ghetko D, Botsch J, Hehl L, Kostrhon S, et al.
Angew Chem Int Ed Engl
. 2023 Jun;
62(32):e202303319.
PMID: 37272691
Protein post-translational modification with ubiquitin (Ub) is a versatile signal regulating almost all aspects of cell biology, and an increasing range of diseases is associated with impaired Ub modification. In...