Paul M M Weers
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Explore the profile of Paul M M Weers including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Dwivedi P, Rodriguez J, Ibe N, Weers P
Biochemistry
. 2016 Jun;
55(26):3607-15.
PMID: 27280697
Apolipophorin III (apoLp-III) is an exchangeable apolipoprotein found in insects and plays an important function in lipid transport. The protein has an unusual five-helix bundle architecture, deviating from the common...
12.
Weers P, Prenner E, Curic S, Lohmeier-Vogel E
Biochem Mol Biol Educ
. 2015 Nov;
44(1):86-94.
PMID: 26560199
The laboratory protocol presented here takes about 3 hours to perform and investigates protein and lipid interactions. Students first purify His6 -tagged human apolipoprotein A-I (apoA-I) with Ni-NTA affinity resin...
13.
Crowhurst K, Horn J, Weers P
Biomol NMR Assign
. 2015 Oct;
10(1):143-7.
PMID: 26493308
Apolipophorin III, a 163 residue monomeric protein from the greater wax moth Galleria mellonella (abbreviated as apoLp-IIIGM), has roles in upregulating expression of antimicrobial proteins as well as binding and...
14.
Thistle J, Martinon D, Weers P
Chem Phys Lipids
. 2015 Oct;
193:18-23.
PMID: 26462904
Apolipophorin III (apoLp-III) from Galleria mellonella is a critical apolipoprotein aiding in lipid transport and has gained considerable interest for a role in innate immunity. Both functions are likely related...
15.
Beck W, Adams C, Biglang-Awa I, Patel A, Vincent H, Haas-Stapleton E, et al.
Biochim Biophys Acta
. 2013 Mar;
1828(6):1503-10.
PMID: 23454085
Human apolipoprotein A-I (apoA-I) is a 28kDa protein and a major component of high-density lipoproteins, mediating several essential metabolic functions related to heart disease. In the present study the potential...
16.
Oztug M, Martinon D, Weers P
Biochemistry
. 2012 Jul;
51(31):6220-7.
PMID: 22779761
Apolipoproteins are able to associate with lipopolysaccharides (LPS), potentially providing protection against septic shock. To gain insight into the molecular details of this binding interaction, apolipophorin III (apoLp-III) from Galleria...
17.
Kamei A, Hauser P, Beckstead J, Weers P, Ryan R
Protein Expr Purif
. 2012 Apr;
83(2):113-6.
PMID: 22487214
Expressed protein ligation (EPL) was performed to investigate sequence requirements for a variant human apolipoprotein A-I (apoA-I) to adopt a folded structure. A C-terminal truncated apoA-I, corresponding to residues 1-172,...
18.
Moreno-Habel D, Biglang-Awa I, Dulce A, Luu D, Garcia P, Weers P, et al.
J Invertebr Pathol
. 2012 Mar;
110(1):92-101.
PMID: 22401766
Antimicrobial peptides are generated in insects exposed to pathogens for combating infection. Gloverin is a small cationic antibacterial protein whose expression is induced in the hemocytes and fat body cells...
19.
Wan C, Chiu M, Wu X, Lee S, Prenner E, Weers P
Biochim Biophys Acta
. 2010 Nov;
1808(3):606-13.
PMID: 21111706
Apolipoprotein mediated formation of nanodisks was studied in detail using apolipophorin III (apoLp-III), thereby providing insight in apolipoprotein-lipid binding interactions. The spontaneous solubilization of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles occured only in...
20.
Weers P, Patel A, Wan L, Guigard E, Kay C, Hafiane A, et al.
J Lipid Res
. 2010 Oct;
52(1):35-44.
PMID: 20884842
We have identified a novel mutation in apoA-I (serine 36 to alanine; S36A) in a human subject with severe hypoalphalipoproteinemia. The mutation is located in the N-terminal region of the...