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Paul L Greenhaff

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Articles 118
Citations 2841
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Recent Articles
21.
Chee C, Shannon C, Burns A, Selby A, Wilkinson D, Smith K, et al.
Aging Cell . 2021 Jan; 20(2):e13303. PMID: 33464721
Intramyocellular lipid (IMCL) utilization is impaired in older individuals, and IMCL accumulation is associated with insulin resistance. We hypothesized that increasing muscle total carnitine content in older men would increase...
22.
Betry C, Nixon A, Greenhaff P, Simpson E
Exp Clin Endocrinol Diabetes . 2020 Oct; 130(1):49-54. PMID: 33096578
Introduction: Skeletal muscle is a major site for whole-body glucose disposal, and determination of skeletal muscle glucose uptake is an important metabolic measurement, particularly in research focussed on interventions that...
23.
Sayda M, Phillips B, Williams J, Greenhaff P, Wilkinson D, Smith K, et al.
Nutrients . 2020 Oct; 12(10). PMID: 33023275
Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However,...
24.
Ward T, Lindley M, Ferguson R, Constantin D, Singh S, Bolton C, et al.
Chest . 2020 Sep; 159(2):564-574. PMID: 32888931
Background: Eccentric cycling (ECC) may be an attractive exercise method in COPD because of both low cardiorespiratory demand and perception of effort compared with conventional concentric cycling (CON) at matched...
25.
Chien H, Greenhaff P, Constantin-Teodosiu D
Int J Mol Sci . 2020 Aug; 21(16). PMID: 32824862
The mechanisms behind the reduction in muscle pyruvate dehydrogenase complex (PDC)-controlled carbohydrate (CHO) oxidation during chronic high-fat dietary intake are poorly understood, as is the basis of CHO oxidation restoration...
26.
Mallinson J, Taylor T, Constantin-Teodosiu D, Billeter-Clark R, Constantin D, Franchi M, et al.
Scand J Med Sci Sports . 2020 Aug; 30(11):2101-2115. PMID: 32762021
High-load eccentric training reputedly produces greater muscle hypertrophy than concentric training, possibly due to greater loading and/or inflammation. We quantified the temporal impact of combined maximal concentric-eccentric training vs maximal...
27.
Atkins R, Constantin-Teodosiu D, Varadhan K, Constantin D, Lobo D, Greenhaff P
Clin Nutr . 2020 Jul; 40(3):1046-1051. PMID: 32711950
Background & Aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP...
28.
Lunt E, Ong T, Gordon A, Greenhaff P, Gladman J
Age Ageing . 2020 Jul; 50(1):88-95. PMID: 32706848
Background: sarcopenia is the loss of muscle mass and quality and is diagnosed using measures of muscle strength, size and mass. We evaluated the literature on whether sarcopenia measures are...
29.
Casanova-Vallve N, Constantin-Teodosiu D, Filer A, Hardy R, Greenhaff P, Chapman V
PLoS One . 2020 Jul; 15(7):e0235702. PMID: 32634159
Rheumatoid arthritis (RA) is accompanied by pain, inflammation and muscle weakness. Skeletal muscle inflammation and inactivity are independently associated with muscle insulin resistance and atrophy. Our objective was to identify...
30.
Wilkinson D, Rodriguez-Blanco G, Dunn W, Phillips B, Williams J, Greenhaff P, et al.
Aging (Albany NY) . 2020 Jun; 12(13):12517-12533. PMID: 32580166
Ageing compromises skeletal muscle mass and function through poorly defined molecular aetiology. Here we have used untargeted metabolomics using UHPLC-MS to profile muscle tissue from young (=10, 25±4y), middle aged...