James A Timmons
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Explore the profile of James A Timmons including associated specialties, affiliations and a list of published articles.
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72
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4071
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Recent Articles
1.
Mcleod J, Lim C, Stokes T, Sharif J, Zeynalli V, Wiens L, et al.
NAR Mol Med
. 2024 Dec;
1(4):ugae016.
PMID: 39669123
A majority of human genes produce non-protein-coding RNA (ncRNA), and some have roles in development and disease. Neither ncRNA nor human skeletal muscle is ideally studied using short-read sequencing, so...
2.
Mcleod J, Lim C, Stokes T, Sharif J, Zeynalli V, Wiens L, et al.
bioRxiv
. 2024 Oct;
PMID: 39416175
A majority of human genes produce non-protein-coding RNA (ncRNA), and some have roles in development and disease. Neither ncRNA nor human skeletal muscle is ideally studied using short-read sequencing, so...
3.
4.
Stokes T, Cen H, Kapranov P, Gallagher I, Pitsillides A, Volmar C, et al.
Adv Genet (Hoboken)
. 2023 Jun;
4(2):2200024.
PMID: 37288167
Sequencing the human genome empowers translational medicine, facilitating transcriptome-wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short-read RNA sequencing...
5.
Dennison J, Volmar C, Modarresi F, Ke D, Wang J, Gravel E, et al.
J Alzheimers Dis
. 2022 Jun;
88(1):385.
PMID: 35723129
No abstract available.
6.
Nath M, Romaine S, Koekemoer A, Hamby S, Webb T, Nelson C, et al.
Eur J Heart Fail
. 2022 May;
24(6):1009-1019.
PMID: 35570197
Aims: Chronic heart failure (CHF) is a systemic syndrome with a poor prognosis and a need for novel therapies. We investigated whether whole blood transcriptomic profiling can provide new mechanistic...
7.
Timmons J, Anighoro A, Brogan R, Stahl J, Wahlestedt C, Farquhar D, et al.
Elife
. 2022 Jan;
11.
PMID: 35037854
Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro...
8.
Dennison J, Volmar C, Modarresi F, Ke D, Wang J, Gravel E, et al.
J Alzheimers Dis
. 2022 Jan;
86(1):173-190.
PMID: 35034905
Background: Alzheimer's disease (AD) has minimally effective treatments currently. High concentrations of resveratrol, a polyphenol antioxidant found in plants, have been reported to affect several AD-related and neuroprotective genes. To...
9.
Cen H, Hussein B, Botezelli J, Wang S, Zhang J, Noursadeghi N, et al.
FASEB J
. 2021 Dec;
36(1):e22088.
PMID: 34921686
Hyperinsulinemia is commonly viewed as a compensatory response to insulin resistance, yet studies have demonstrated that chronically elevated insulin may also drive insulin resistance. The molecular mechanisms underpinning this potentially...
10.
Stokes T, Timmons J, Crossland H, Tripp T, Murphy K, McGlory C, et al.
Cell Rep
. 2020 Aug;
32(5):107980.
PMID: 32755574
Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators. A within-person...