Paul E Bourgine
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Explore the profile of Paul E Bourgine including associated specialties, affiliations and a list of published articles.
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18
Citations
306
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Recent Articles
1.
Liu Y, Puthia M, Sheehy E, Ambite I, Petrlova J, Prithviraj S, et al.
Acta Biomater
. 2023 Mar;
162:164-181.
PMID: 36967054
Despite the glimmer of hope provided by the discovery and commercialization of bone morphogenetic protein-2 (BMP-2) as a bone graft substitute, side effects related to the use of supraphysiological doses...
2.
Dupard S, Garcia Garcia A, Bourgine P
Front Bioeng Biotechnol
. 2023 Jan;
10:1081145.
PMID: 36698631
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of design flexibility and complex...
3.
Grigoryan A, Zacharaki D, Balhuizen A, Come C, Garcia Garcia A, Hidalgo Gil D, et al.
Sci Transl Med
. 2022 Oct;
14(666):eabm6391.
PMID: 36223446
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of...
4.
Garcia-Garcia A, Klein T, Born G, Hilpert M, Scherberich A, Lengerke C, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(40).
PMID: 34580200
Human malignant hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) niches, which remain challenging to explore due to limited in vivo accessibility and constraints with humanized animal...
5.
Pigeot S, Klein T, Gullotta F, Dupard S, Garcia Garcia A, Garcia-Garcia A, et al.
Adv Mater
. 2021 Sep;
33(43):e2103737.
PMID: 34486186
Design criteria for tissue-engineered materials in regenerative medicine include robust biological effectiveness, off-the-shelf availability, and scalable manufacturing under standardized conditions. For bone repair, existing strategies rely on primary autologous cells,...
6.
Dupard S, Bourgine P
Methods Mol Biol
. 2021 May;
2308:253-262.
PMID: 34057728
The hematopoietic microenvironment, also referred to as hematopoietic niche, is a functional three-dimensional (3D) unit of the bone marrow (BM) that planar culture systems cannot recapitulate. Existing limitations of 2D...
7.
De Santis M, Alsafadi H, Tas S, Bolukbas D, Prithiviraj S, Da Silva I, et al.
Adv Mater
. 2020 Dec;
33(3):e2005476.
PMID: 33300242
Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here,...
8.
Sommerkamp P, Mercier F, Wilkinson A, Bonnet D, Bourgine P
Exp Hematol
. 2020 Dec;
94:20-25.
PMID: 33278488
The bone marrow microenvironment contains cellular niches that maintain the pool of hematopoietic stem and progenitor cells and support hematopoietic maturation. Malignant hematopoietic cells also co-opt normal cellular interactions to...
9.
Dupard S, Grigoryan A, Farhat S, Coutu D, Bourgine P
Trends Mol Med
. 2020 May;
26(6):552-569.
PMID: 32470383
Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived...
10.
Bourgine P, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris K, et al.
iScience
. 2019 Aug;
19:504-513.
PMID: 31442666
The generation of humanized ectopic ossicles (hOss) in mice has been proposed as an advanced translational and fundamental model to study the human hematopoietic system. The approach relies on the...