Daniel L Coutu
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Explore the profile of Daniel L Coutu including associated specialties, affiliations and a list of published articles.
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22
Citations
791
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Recent Articles
1.
Rindone A, Liu X, Farhat S, Perdomo-Pantoja A, Witham T, Coutu D, et al.
Nat Commun
. 2021 Oct;
12(1):6219.
PMID: 34711819
Vascularization is critical for skull development, maintenance, and healing. Yet, there remains a significant knowledge gap in the relationship of blood vessels to cranial skeletal progenitors during these processes. Here,...
2.
Kunz L, Coutu D
Methods Mol Biol
. 2021 Jul;
2350:95-104.
PMID: 34331281
In multicellular organisms, most physiological and pathological processes involve an interplay between various cells and molecules that act both locally and systemically. To understand how these complex and dynamic processes...
3.
Dupard S, Grigoryan A, Farhat S, Coutu D, Bourgine P
Trends Mol Med
. 2020 May;
26(6):552-569.
PMID: 32470383
Ectopic 'humanized ossicles' (hOss) are miniaturized, engineered human bone organs in mice displaying a similar structure and function to native mouse bones. However, they are composed of human mesenchymal derived...
4.
Bourgine P, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris K, et al.
iScience
. 2019 Aug;
19:504-513.
PMID: 31442666
The generation of humanized ectopic ossicles (hOss) in mice has been proposed as an advanced translational and fundamental model to study the human hematopoietic system. The approach relies on the...
5.
Bourgine P, Klein T, Paczulla A, Shimizu T, Kunz L, Kokkaliaris K, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(25):E5688-E5695.
PMID: 29866839
In adults, human hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) microenvironment. Our understanding of human hematopoiesis and the associated niche biology remains limited, due to...
6.
Hastreiter S, Skylaki S, Loeffler D, Reimann A, Hilsenbeck O, Hoppe P, et al.
Stem Cell Reports
. 2018 May;
11(1):58-69.
PMID: 29779897
Embryonic stem cells (ESCs) display heterogeneous expression of pluripotency factors such as Nanog when cultured with serum and leukemia inhibitory factor (LIF). In contrast, dual inhibition of the signaling kinases...
7.
Coutu D, Kokkaliaris K, Kunz L, Schroeder T
Nat Methods
. 2018 Jan;
15(1):39-46.
PMID: 29320487
Multicolor 3D quantitative imaging of large tissue volumes is necessary to understand tissue development and organization as well as interactions between distinct cell types in situ. However, tissue imaging remains...
8.
Coutu D, Kokkaliaris K, Kunz L, Schroeder T
Nat Biotechnol
. 2017 Nov;
35(12):1202-1210.
PMID: 29131149
The bone marrow (BM) microenvironment contains many types of cells and molecules with roles in hematopoiesis, osteogenesis, angiogenesis and metabolism. The spatial distribution of the different bone and BM cell...
9.
Hoppe P, Schwarzfischer M, Loeffler D, Kokkaliaris K, Hilsenbeck O, Moritz N, et al.
Nature
. 2016 Jul;
535(7611):299-302.
PMID: 27411635
The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-affiliated transcription factors with the capacity for lineage reprogramming, positive auto-regulation and mutual inhibition have been described as being expressed in uncommitted...
10.
Coutu D, Mahfouz W, Loutochin O, Galipeau J, Corcos J
PLoS One
. 2014 Dec;
9(12):e111966.
PMID: 25437001
Bladder replacement or augmentation is required in congenital malformations or following trauma or cancer. The current surgical solution involves enterocystoplasty but is associated with high complication rates. Strategies for bladder...