Timm Schroeder
Overview
Explore the profile of Timm Schroeder including associated specialties, affiliations and a list of published articles.
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Articles
161
Citations
7004
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0
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Recent Articles
1.
Volta L, Myburgh R, Hofstetter M, Koch C, Kiefer J, Gobbi C, et al.
Hemasphere
. 2024 Nov;
8(11):e70055.
PMID: 39564539
Acute myeloid leukemia (AML) derives from hematopoietic stem and progenitor cells (HSPCs). To date, no AML-exclusive, non-HSPC-expressed cell-surface target molecules for AML selective immunotherapy have been identified. Therefore, to still...
2.
Volta L, Myburgh R, Pellegrino C, Koch C, Maurer M, Manfredi F, et al.
Leukemia
. 2024 Sep;
38(12):2598-2613.
PMID: 39294295
CAR T-cell products targeting lineage-specific cell-of-origin antigens, thereby eliminating both tumor and healthy counterpart cells, are currently clinically approved therapeutics in B- and plasma-cell malignancies. While they represent a major...
3.
Arekatla G, Skylaki S, Corredor Suarez D, Jackson H, Schapiro D, Engler S, et al.
Nat Commun
. 2024 Sep;
15(1):7860.
PMID: 39251590
Pluripotent mouse embryonic stem cells (ESCs) can differentiate to all germ layers and serve as an in vitro model of embryonic development. To better understand the differentiation paths traversed by...
4.
Schirmacher D, Armagan U, Zhang Y, Kull T, Auler M, Schroeder T
PLoS Comput Biol
. 2024 Aug;
20(8):e1012361.
PMID: 39178193
Segmentation is required to quantify cellular structures in microscopic images. This typically requires their fluorescent labeling. Convolutional neural networks (CNNs) can detect these structures also in only transmitted light images....
5.
Mueller J, Schimmer R, Koch C, Schneiter F, Fullin J, Lysenko V, et al.
EMBO Mol Med
. 2024 Feb;
16(3):445-474.
PMID: 38355749
TP53-mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells might be a promising therapeutic...
6.
Rai S, Zhang Y, Grockowiak E, Kimmerlin Q, Hansen N, Stoll C, et al.
Blood Adv
. 2024 Jan;
8(5):1234-1249.
PMID: 38207211
JAK 2-V617F is the most frequent somatic mutation causing myeloproliferative neoplasm (MPN). JAK2-V617F can be found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP) with a frequency much...
7.
Arekatla G, Trenzinger C, Reimann A, Loeffler D, Kull T, Schroeder T
Dev Cell
. 2023 May;
58(12):1022-1036.e4.
PMID: 37207652
ERK and AKT signaling control pluripotent cell self-renewal versus differentiation. ERK pathway activity over time (i.e., dynamics) is heterogeneous between individual pluripotent cells, even in response to the same stimuli....
8.
Reimann A, Kull T, Wang W, Dettinger P, Loeffler D, Schroeder T
Stem Cell Reports
. 2023 May;
18(6):1295-1307.
PMID: 37207650
Signaling is central in cell fate regulation, and relevant information is encoded in its activity over time (i.e., dynamics). However, simultaneous dynamics quantification of several pathways in single mammalian stem...
9.
Grabnitz F, Stark D, Shlesinger D, Petkidis A, Borsa M, Yermanos A, et al.
Cell Rep
. 2023 May;
42(5):112468.
PMID: 37178119
The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric cell division (ACD) as...
10.
Stetka J, Usart M, Kubovcakova L, Rai S, Rao T, Sutter J, et al.
Blood
. 2023 Feb;
141(17):2127-2140.
PMID: 36758212
JAK 2-V617F mutation causes myeloproliferative neoplasms (MPNs) that can manifest as polycythemia vera (PV), essential thrombocythemia (ET), or primary myelofibrosis. At diagnosis, patients with PV already exhibited iron deficiency, whereas...