Paul Awolade
Overview
Explore the profile of Paul Awolade including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
216
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0
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Recent Articles
1.
Sala R, Esquer H, Kellett T, Clune S, Awolade P, Pike L, et al.
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684869
Colorectal cancer (CRC) is one of the most prevalent and deadly forms of cancer. It is universally treated with a combination of the DNA damaging chemotherapy drugs irinotecan, 5-Fluorouracil (5-FU),...
2.
Sala R, Esquer H, Kellett T, Kearns J, Awolade P, Zhou Q, et al.
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201277
The Chromodomain helicase DNA-binding protein 1-like (CHD1L) is a nucleosome remodeling enzyme, which plays a key role in chromatin relaxation during the DNA damage response. Genome editing has shown that...
3.
Sallomy C, Awolade P, Rahnasto-Rilla M, Hamalainen M, Nousiainen L, Johansson N, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1221-1226.
PMID: 39140042
Transient receptor potential ankyrin 1 (TRPA1) protein plays an important role in the inflammatory response, and it has been associated with different pain conditions and pain-related diseases, making TRPA1 a...
4.
Cele N, Awolade P, Seboletswe P, Khubone L, Olofinsan K, Islam M, et al.
ChemistryOpen
. 2024 Mar;
13(9):e202400014.
PMID: 38506589
Two libraries of quinoline-based hybrids 1-(7-chloroquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and 7-chloro-N-phenylquinolin-4-amine were synthesized and evaluated for their α-glucosidase inhibitory and antioxidant properties. Compounds with 4-methylpiperidine and para-trifluoromethoxy groups, respectively, showed the most promising...
5.
Clune S, Awolade P, Zhou Q, Esquer H, Matter B, Kearns J, et al.
Biomed Pharmacother
. 2023 Dec;
170:116037.
PMID: 38128184
Chromodomain helicase DNA-binding protein 1 like (CHD1L) is an oncogene that promotes tumor progression, metastasis, and multidrug resistance. CHD1L expression is indicative of poor outcomes and low survival in cancer...
6.
Ebenezer O, Bodede O, Awolade P, Jordaan M, Ogunsakin R, Shapi M
Acta Pharm
. 2023 Jan;
72(2):199-224.
PMID: 36651508
The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of...
7.
Cele N, Awolade P, Seboletswe P, Olofinsan K, Islam M, Singh P
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015183
Diabetes mellitus (DM) is a multifaceted metabolic disorder that remains a major threat to global health security. Sadly, the clinical relevance of available drugs is burdened with an upsurge in...
8.
Shalini , Pankaj , Saha S, Kaur M, Oluwakemi E, Awolade P, et al.
RSC Adv
. 2022 May;
10(27):15836-15845.
PMID: 35493668
A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, MCF-7 (ER+), and triple-negative, MDA-MB-231 (ER-), cell lines. The structure-activity-relationship (SAR) was deduced...
9.
Prigaro B, Esquer H, Zhou Q, Pike L, Awolade P, Lai X, et al.
J Med Chem
. 2022 Feb;
65(5):3943-3961.
PMID: 35192363
Chromodomain helicase DNA-binding protein 1 like (CHD1L) is an oncogene implicated in tumor progression, multidrug resistance, and metastasis in many types of cancer. In this article, we described the optimization...
10.
Gummidi L, Kerru N, Ebenezer O, Awolade P, Sanni O, Islam M, et al.
Bioorg Chem
. 2021 Jul;
115:105210.
PMID: 34332231
A simple and efficient protocol was developed to synthesize a new library of thiazolidine-4-one molecular hybrids (4a-n) via a one-pot multicomponent reaction involving 5-substituted phenyl-1,3,4-thiadiazol-2-amines, substituted benzaldehydes and 2-mercaptoacetic acid....