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Parvesh Singh

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Articles 75
Citations 675
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Recent Articles
1.
Kumar G, Seboletswe P, Mishra S, Manhas N, Ghumran S, Kerru N, et al.
ChemMedChem . 2025 Mar; :e202400949. PMID: 40067058
In this study, we designed and synthesized a new series of  isoniazid-dihydropyrimidinone molecular hybrids (8a-8n). All compounds were structurally characterized using spectroscopic techniques viz., FTIR, NMR (1H, 13C, HMBC, and...
2.
Shaik B, Moodley K, Ghumran S, Bala M, Singh P, Karpoormath R
Med Res Rev . 2025 Feb; PMID: 39916319
Antitubercular drug discovery progress in the last decade, especially research on the biological function, target inhibition and diagnosis of tuberculosis (TB) diagnosis has considerably advanced. The application of target-based drug...
3.
Shaik B, Tembe N, Kajee A, Ngcobo Z, Ghai M, Obakachi V, et al.
Chem Biodivers . 2025 Jan; :e202402644. PMID: 39876518
A new series of quinoline-Schiff bases was designed and synthesized using a straightforward and efficient methodology involving the condensation of 2-chloroquinoline-3-carbaldehyde with substituted aromatic amines. A total of 17 quinoline-Schiff...
4.
Manhas N, Kumar G, Dhawan S, Makhanya T, Singh P
ChemistryOpen . 2025 Jan; e202400439. PMID: 39871708
Quinazolines/quinazolin-4-ones are significant nitrogen-containing heterocycles that exist in various natural products and synthetic scaffolds with diverse medicinal and pharmacological applications. Researchers across the globe have explored numerous synthetic strategies to...
5.
Magaji B, Singh P, Skelton A, Martincigh B
Heliyon . 2024 Nov; 10(21):e39910. PMID: 39583804
The aim of this research was to provide valuable insights on symmetrical α,β-unsaturated ketones as potential chemical ultraviolet (UV) filters from experimental data and theoretical aspects. Towards this end, density...
6.
Seboletswe P, Kumar G, Gcabashe N, Olofinsan K, Islam S, Idris A, et al.
Chem Biodivers . 2024 Nov; 22(3):e202401556. PMID: 39530612
Diabetes mellitus (DM) is a metabolic condition that is a profound health concern across the globe due to its contribution to the increased mortality rate. It affects millions of people...
7.
Kumar G, Seboletswe P, Gcabashe N, Dhawan S, Manhas N, Bhargava G, et al.
ChemistryOpen . 2024 Oct; 14(2):e202400198. PMID: 39460430
A greener, safer, and more efficient methodology for the synthesis of (Z)-5-benzylidene-2-thioxothiazolidin-4-ones (3 a-u) and (Z)-5-benzylidenethiazolidine-2,4-diones (4 a-i) has been developed. The deep eutectic solvent (DES) ZnCl/urea used as a...
8.
Chaudhuri R, Meyer T, Blinder R, Vethamuthu M, George V, Adeniyi A, et al.
Int J Cosmet Sci . 2024 Aug; 47(1):73-90. PMID: 39134925
Background: Use of permanent hair dyes causes unintended oxidative damage during the short time frame of the dyeing process that leads to perceivable changes in the feel, manageability and appearance...
9.
Dhawan S, Singh A, Manhas N, Seboletswe P, Khubone L, Kumar G, et al.
ChemMedChem . 2024 Jul; 19(22):e202400297. PMID: 39015094
In the present study, we identified that two representative compounds (7 c and 9 f) of our newly synthesized coumarin-tagged bis-triazoles induced apoptosis in human pancreatic cells (PANC-1) by caspase...
10.
Cele N, Awolade P, Seboletswe P, Khubone L, Olofinsan K, Islam M, et al.
ChemistryOpen . 2024 Mar; 13(9):e202400014. PMID: 38506589
Two libraries of quinoline-based hybrids 1-(7-chloroquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and 7-chloro-N-phenylquinolin-4-amine were synthesized and evaluated for their α-glucosidase inhibitory and antioxidant properties. Compounds with 4-methylpiperidine and para-trifluoromethoxy groups, respectively, showed the most promising...