Paul A Townsend
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Explore the profile of Paul A Townsend including associated specialties, affiliations and a list of published articles.
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112
Citations
2992
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Recent Articles
1.
Kim M, Brustad N, Eliasen A, Ali M, Wang T, Rasmussen M, et al.
Med
. 2024 Aug;
5(12):1485-1494.e3.
PMID: 39151420
Background: Bilirubin has antioxidant properties, and elevated levels within the normal range have been associated with improved lung function and decreased risk of asthma in adults, but studies of young...
2.
Kipura T, Hotze M, Hofer A, Egger A, Timpen L, Opitz C, et al.
Metabolites
. 2024 Jul;
14(7).
PMID: 39057693
Amino acids (AAs) and their metabolites are important building blocks, energy sources, and signaling molecules associated with various pathological phenotypes. The quantification of AA and tryptophan (TRP) metabolites in human...
3.
Kim M, Norrisgaard P, Vahman N, Cexus O, Townsend P, Stokholm J, et al.
Nutrients
. 2024 Feb;
16(3).
PMID: 38337692
We previously demonstrated a beneficial effect of high-dose vitamin D in pregnancy on offspring bone and dental health. Here, we investigated the effect of maternal dietary patterns during pregnancy on...
4.
Spick M, Muazzam A, Pandha H, Michael A, Gethings L, Hughes C, et al.
Heliyon
. 2023 Dec;
9(12):e22604.
PMID: 38076065
There is an unmet need for improved diagnostic testing and risk prediction for cases of prostate cancer (PCa) to improve care and reduce overtreatment of indolent disease. Here we have...
5.
Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, et al.
Nat Genet
. 2023 Nov;
55(12):2065-2074.
PMID: 37945903
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry...
6.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
Am J Hum Genet
. 2023 Jun;
110(7):1200-1206.
PMID: 37311464
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
7.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
medRxiv
. 2023 Jun;
PMID: 37292833
Genome-wide polygenic risk scores (GW-PRS) have been reported to have better predictive ability than PRS based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
8.
Muazzam A, Spick M, Cexus O, Geary B, Azhar F, Pandha H, et al.
Cancers (Basel)
. 2023 Feb;
15(4).
PMID: 36831393
Prostate cancer is the most common malignant tumour in men. Improved testing for diagnosis, risk prediction, and response to treatment would improve care. Here, we identified a proteomic signature of...
9.
Lewis H, Gupta P, Saunders K, Briones S, von Gerichten J, Townsend P, et al.
Analyst
. 2023 Feb;
148(5):1041-1049.
PMID: 36723178
This work describes the development of a new approach to measure drug levels and lipid fingerprints in single living mammalian cells. Nanocapillary sampling is an approach that enables the selection...
10.
Zamyatnin Jr A, Gregory L, Townsend P, Soond S
Expert Opin Ther Targets
. 2022 Dec;
26(11):963-977.
PMID: 36562407
Introduction: In view of other candidate proteins from the cathepsin family of proteases holding great potential in being targeted during cancer therapy, the importance of Cathepsin B (CtsB) stands out...