Marek M Nagiec
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Explore the profile of Marek M Nagiec including associated specialties, affiliations and a list of published articles.
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10
Citations
282
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Recent Articles
1.
Nagiec M, Duvall J, Skepner A, Howe E, Bastien J, Comer E, et al.
Medchemcomm
. 2018 Dec;
9(11):1831-1842.
PMID: 30542533
Increased expression of the Tribbles pseudokinase 1 gene () is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary...
2.
Schnute M, McReynolds M, Carroll J, Chrencik J, Highkin M, Iyanar K, et al.
J Med Chem
. 2017 Feb;
60(6):2562-2572.
PMID: 28231433
Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival, and migration and is a key regulator...
3.
Nagiec M, Skepner A, Negri J, Eichhorn M, Kuperwasser N, Comer E, et al.
PLoS One
. 2015 Mar;
10(3):e0120295.
PMID: 25811180
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion...
4.
Dockendorff C, Nagiec M, Weiwer M, Buhrlage S, Ting A, Nag P, et al.
ACS Med Chem Lett
. 2012 Oct;
3(10):808-813.
PMID: 23074541
Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the previously reported macrocycle robotnikinin. Analogues were prepared using a modular and efficient build-couple-pair...
5.
Schnute M, McReynolds M, Kasten T, Yates M, Jerome G, Rains J, et al.
Biochem J
. 2012 Mar;
444(1):79-88.
PMID: 22397330
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key...
6.
Highkin M, Yates M, Nemirovskiy O, LaMarr W, Munie G, Rains J, et al.
J Biomol Screen
. 2011 Feb;
16(2):272-7.
PMID: 21297110
To facilitate discovery of compounds modulating sphingosine-1-phosphate (S1P) signaling, the authors used high-throughput mass spectrometry technology to measure S1P formation in human whole blood. Since blood contains endogenous sphingosine (SPH)...
7.
Aeed P, Young C, Nagiec M, Elhammer A
Antimicrob Agents Chemother
. 2008 Dec;
53(2):496-504.
PMID: 19047657
By using a detergent-washed membrane preparation, the interaction of the fungal natural product inhibitor aureobasidin A (AbA) with inositol phosphorylceramide synthase (IPC synthase) was studied by kinetic analysis of wild-type...
8.
Aeed P, Sperry A, Young C, Nagiec M, Elhammer A
Biochemistry
. 2004 Jun;
43(26):8483-93.
PMID: 15222759
The effect of 26 different membrane-perturbing agents on the activity and phase distribution of inositol phosphorylceramide synthase (IPC synthase) activity in crude Candida albicans membranes was investigated. The nonionic detergents...
9.
Nagiec M, Young C, Zaworski P, Kobayashi S
Biochem Biophys Res Commun
. 2003 Jul;
307(2):369-74.
PMID: 12859966
Standard methods for evaluating the target specificity of antimicrobial agents often involve the use of microorganisms with altered expression of selected targets and thus either more resistant or more susceptible...
10.
Kobayashi S, Nagiec M
Eukaryot Cell
. 2003 Apr;
2(2):284-94.
PMID: 12684378
Sphingolipid precursors, namely, ceramide and long-chain base phosphates (LCBPs), are important growth regulators with often opposite effects on mammalian cells. A set of enzymes that regulate the levels of these...