Patrick L Splinter
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Explore the profile of Patrick L Splinter including associated specialties, affiliations and a list of published articles.
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48
Citations
2393
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Recent Articles
1.
Victorelli S, Eppard M, Woo S, Everts S, Martini H, Pirius N, et al.
Res Sq
. 2024 Sep;
PMID: 39257994
Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial...
2.
Kang J, Splinter P, Trussoni C, Pirius N, Gores G, LaRusso N, et al.
Gastroenterology
. 2023 Apr;
165(1):228-243.e2.
PMID: 37059338
Background & Aims: We reported that cholangiocyte senescence, regulated by the transcription factor ETS proto-oncogene 1 (ETS1), is a pathogenic feature of primary sclerosing cholangitis (PSC). Furthermore, histone 3 lysine...
3.
Al Suraih M, Trussoni C, Splinter P, LaRusso N, OHara S
Liver Int
. 2020 Jun;
40(10):2455-2468.
PMID: 32558183
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by peribiliary inflammation and fibrosis. Cholangiocyte senescence is a prominent feature of PSC. Here, we hypothesize that...
4.
OHara S, Splinter P, Trussoni C, Guicciardi M, Splinter N, Al Suraih M, et al.
J Biol Chem
. 2019 Oct;
294(49):18698-18713.
PMID: 31659122
Primary sclerosing cholangitis (PSC) is an idiopathic, progressive cholangiopathy. Cholangiocyte senescence is important in PSC pathogenesis, and we have previously reported that senescence is regulated by the transcription factor ETS...
5.
Guicciardi M, Trussoni C, Krishnan A, Bronk S, Lorenzo Pisarello M, OHara S, et al.
J Hepatol
. 2018 May;
69(3):676-686.
PMID: 29802947
Background & Aims: Macrophages contribute to liver disease, but their role in cholestatic liver injury, including primary sclerosing cholangitis (PSC), is unclear. We tested the hypothesis that macrophages contribute to...
6.
Moncsek A, Al-Suraih M, Trussoni C, OHara S, Splinter P, Zuber C, et al.
Hepatology
. 2017 Aug;
67(1):247-259.
PMID: 28802066
Conclusion: Bcl-xL is a key survival factor in ASFs as well as in senescent cholangiocytes. Treatment with the Bcl-xL-specific inhibitor, A-1331852, reduces liver fibrosis, possibly by a dual effect on...
7.
OHara S, Splinter P, Trussoni C, Lorenzo Pisarello M, Loarca L, Splinter N, et al.
J Biol Chem
. 2017 Feb;
292(12):4833-4846.
PMID: 28184004
Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory cholangiopathy (disease of the bile ducts) of unknown pathogenesis. We reported that cholangiocyte senescence features prominently in PSC and that neuroblastoma RAS...
8.
Tabibian J, OHara S, Trussoni C, Tietz P, Splinter P, Mounajjed T, et al.
Hepatology
. 2015 Jun;
63(1):185-96.
PMID: 26044703
Unlabelled: Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally important, yet remains obscure. We tested the hypothesis...
9.
Trussoni C, Tabibian J, Splinter P, OHara S
PLoS One
. 2015 Apr;
10(4):e0125793.
PMID: 25915403
Cholangiocytes (biliary epithelial cells) actively participate in microbe-induced proinflammatory responses in the liver and contribute to inflammatory and infectious cholangiopathies. We previously demonstrated that cholangiocyte TLR-dependent NRas activation contributes to...
10.
Tabibian J, Trussoni C, OHara S, Splinter P, Heimbach J, LaRusso N
Lab Invest
. 2014 Jul;
94(10):1126-33.
PMID: 25046437
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy. The role of cholangiocytes (biliary epithelial cells) in PSC pathogenesis is unknown and remains an active area of research. Here, through...