Xian-Ming Chen
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Explore the profile of Xian-Ming Chen including associated specialties, affiliations and a list of published articles.
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88
Citations
3771
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Recent Articles
1.
Sharmin Z, Jin K, Gong A, Deng S, Pok C, Graham M, et al.
Front Immunol
. 2024 Jul;
15:1397117.
PMID: 39040107
Intestinal epithelial cells possess the requisite molecular machinery to initiate cell-intrinsic defensive responses against intracellular pathogens, including intracellular parasites. Interferons(IFNs) have been identified as cornerstones of epithelial cell-intrinsic defense against...
2.
Graham M, Li M, Gong A, Deng S, Jin K, Wang S, et al.
Front Immunol
. 2023 Jun;
14:1205468.
PMID: 37346046
is a zoonotic apicomplexan parasite that infects the gastrointestinal epithelium and other mucosal surfaces in humans. It is an important opportunistic pathogen in AIDS patients and a leading cause of...
3.
Deng S, He W, Gong A, Li M, Wang Y, Xia Z, et al.
Nat Commun
. 2023 Mar;
14(1):1456.
PMID: 36928642
Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no fully effective therapy available for the...
4.
Deng S, Graham M, Chen X
Pathogens
. 2023 Feb;
12(2).
PMID: 36839591
Protozoan parasites, such as , , , , and , are causative agents of health-threatening diseases in both humans and animals, leading to significant health risks and socioeconomic losses globally....
5.
Mathy N, Deng S, Gong A, Li M, Wang Y, Burleigh O, et al.
Front Immunol
. 2022 Apr;
13:863957.
PMID: 35464447
The cells of the intestinal epithelium establish the frontline for host defense against pathogens in the gastrointestinal tract and play a vital role in the initiation of the immune response....
6.
Gong A, Wang Y, Li M, Zhang X, Deng S, Chen J, et al.
mBio
. 2021 Sep;
12(5):e0212721.
PMID: 34488445
Interferon (IFN) signaling is key to mucosal immunity in the gastrointestinal tract, but cellular regulatory elements that determine interferon gamma (IFN-γ)-mediated antimicrobial defense in intestinal epithelial cells are not fully...
7.
Xia Z, Xu J, Lu E, He W, Deng S, Gong A, et al.
Front Immunol
. 2021 Jul;
12:705232.
PMID: 34295340
Increasing evidence supports that N6-methyladenosine (mA) mRNA modification may play an important role in regulating immune responses. Intestinal epithelial cells orchestrate gastrointestinal mucosal innate defense to microbial infection, but underlying...
8.
Xie X, Chen X, Shi L, Liu J
Medicine (Baltimore)
. 2021 Mar;
100(12):e24765.
PMID: 33761638
MicroRNA (miR)-26a-5p is an oncogene significantly associated with osteosarcoma. We try to evaluate expression of circulating miR-26a-5p in osteosarcoma patients and evaluate its significance.A total of 243 consecutive osteosarcoma patients...
9.
Li J, Jin K, Li M, Mathy N, Gong A, Deng S, et al.
PLoS Pathog
. 2021 Jan;
17(1):e1009241.
PMID: 33481946
The gastrointestinal epithelium guides the immune system to differentiate between commensal and pathogenic microbiota, which relies on intimate links with the type I IFN signal pathway. Epithelial cells along the...
10.
He W, Li J, Gong A, Deng S, Li M, Wang Y, et al.
Microorganisms
. 2021 Jan;
9(1).
PMID: 33445463
is a genus of that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in...