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Patricia A Ropp

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Articles 12
Citations 946
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Recent Articles
1.
Hunsucker S, McGary C, Vincent B, Enyenihi A, Waugh J, McKinnon K, et al.
Cancer Immunol Res . 2015 Jan; 3(3):228-35. PMID: 25576336
Testing of T cell-based cancer therapeutics often involves measuring cancer antigen-specific T-cell populations with the assumption that they arise from in vivo clonal expansion. This analysis, using peptide/MHC tetramers, is...
2.
Zhang M, Sukhumalchandra P, Enyenihi A, St John L, Hunsucker S, Mittendorf E, et al.
Clin Cancer Res . 2012 Nov; 19(1):247-57. PMID: 23147993
Purpose: Immunotherapy targeting aberrantly expressed leukemia-associated antigens has shown promise in the management of acute myeloid leukemia (AML). However, because of the heterogeneity and clonal evolution that is a feature...
3.
Holcomb D, Ropp P, Theil E, Thorp H
Inorg Chem . 2009 Dec; 49(3):786-95. PMID: 20038124
Oxidation of RNA can be effected by two different techniques: a photochemical, electron-transfer method termed "flash-quench" and direct oxidation by metal oxo complexes. The flash-quench method produces selective oxidation using...
4.
Gratton S, Ropp P, Pohlhaus P, Luft J, Madden V, Napier M, et al.
Proc Natl Acad Sci U S A . 2008 Aug; 105(33):11613-8. PMID: 18697944
The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have...
5.
Gratton S, Napier M, Ropp P, Tian S, DeSimone J
Pharm Res . 2008 Jul; 25(12):2845-52. PMID: 18592353
Purpose: To investigate the cellular internalization pathways of shape- and size-specific particles as a function of zeta potential in different cell types. Methods: A top-down particle fabrication technique called PRINT...
6.
Petros R, Ropp P, DeSimone J
J Am Chem Soc . 2008 Mar; 130(15):5008-9. PMID: 18355010
A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro. Particles of discrete size and shape (cube side...
7.
Paul J, Kircus S, Sorrell T, Ropp P, Thorp H
Inorg Chem . 2006 Jun; 45(13):5126-35. PMID: 16780335
The presence of the Zn2+ ion dramatically enhances the inhibition of trypsin and tryptase by amidine-modified benzimidazole inhibitors via coordination to both the catalytically active Ser195 hydroxyl and His57 imidazole...
8.
Tibodeau J, Fox P, Ropp P, Theil E, Thorp H
Proc Natl Acad Sci U S A . 2005 Dec; 103(2):253-7. PMID: 16381820
The binding of small molecules to distinctive three-dimensional structures in mRNA provides a new dimension in RNA control, previously limited to the targeting of secondary structures with antisense and RNA...
9.
Gore M, Szalai V, Ropp P, Yang I, Silverman J, Thorp H
Anal Chem . 2003 Dec; 75(23):6586-92. PMID: 14640732
The electrochemical detection of nucleic acid targets at low concentrations has a number of applications in diagnostics and pharmaceutical research. Self-assembled monolayers of alkanethiol-derivatized oligonucleotides on gold electrodes provide a...
10.
Holmberg R, Tierney M, Ropp P, Berg E, Grinstaff M, Thorp H
Inorg Chem . 2003 Sep; 42(20):6379-87. PMID: 14514313
A phosphoramidite containing Os(bpy)(3)(2+) (Os; bpy, 2,2'-bipyridine) with a three-carbon linker was synthesized and used to prepare oligonucleotides with the Os redox catalyst appended to the 5'-end. The electrogenerated Os(III)...