Reductively Labile PRINT Particles for the Delivery of Doxorubicin to HeLa Cells

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2008 Mar 22

PMID 18355010

Citations 28

Authors

Robby A Petros

Patricia A Ropp

Joseph M DeSimone

Affiliations

Soon will be listed here.

Abstract

A Trojan horse PRINT particle composition was developed that incorporates a reductively labile cross-linker to achieve activated release of doxorubicin in vitro. Particles of discrete size and shape (cube side length = 2 micron) containing 30 wt % of a disulfide-based cross-linker and 2 wt % doxorubicin were synthesized. This PRINT composition was shown to release doxorubicin in response to a reducing environment as measured by flow cytometry and was found to be highly proficient at killing HeLa cells in vitro.

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