Pascale Zimmermann
Overview
Explore the profile of Pascale Zimmermann including associated specialties, affiliations and a list of published articles.
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68
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8871
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Recent Articles
1.
Leblanc R, Ghossoub R, Goubard A, Castellano R, Fares J, Camoin L, et al.
EMBO Mol Med
. 2023 Oct;
15(11):e17570.
PMID: 37819151
The crosstalk between cancer and stromal cells plays a critical role in tumor progression. Syntenin is a small scaffold protein involved in the regulation of intercellular communication that is emerging...
2.
Castro-Cruz M, Hyka L, Daaboul G, Leblanc R, Meeussen S, Lembo F, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2310914120.
PMID: 37695903
Extracellular vesicles (EVs) are membrane-limited organelles mediating cell-to-cell communication in health and disease. EVs are of high medical interest, but their rational use for diagnostics or therapies is restricted by...
3.
Castro-Cruz M, Lembo F, Borg J, Trave G, Vincentelli R, Zimmermann P
Membranes (Basel)
. 2023 Aug;
13(8).
PMID: 37623798
PSD95-disc large-zonula occludens (PDZ) domains are globular modules of 80-90 amino acids that co-evolved with multicellularity. They commonly bind to carboxy-terminal sequences of a plethora of membrane-associated proteins and influence...
4.
Fan Y, Pionneau C, Cocozza F, Boelle P, Chardonnet S, Charrin S, et al.
J Extracell Vesicles
. 2023 Aug;
12(8):e12352.
PMID: 37525398
The tetraspanins CD9, CD81 and CD63 are major components of extracellular vesicles (EVs). Yet, their impact on EV composition remains under-investigated. In the MCF7 breast cancer cell line CD63 was...
5.
Hoffer L, Garcia M, Leblanc R, Feracci M, Betzi S, Ben Yaala K, et al.
J Med Chem
. 2023 Mar;
66(7):4633-4658.
PMID: 36939673
The rapid identification of early hits by fragment-based approaches and subsequent hit-to-lead optimization represents a challenge for drug discovery. To address this challenge, we created a strategy called "DOTS" that...
6.
Thuault S, Ghossoub R, David G, Zimmermann P
Front Cell Dev Biol
. 2022 Jun;
10:886381.
PMID: 35669514
Matrix metalloproteinases (MMPs) are key players in matrix remodeling and their function has been particularly investigated in cancer biology. Indeed, through extracellular matrix (ECM) degradation and shedding of diverse cell...
7.
Ghossoub R, Leblanc R, David G, Zimmermann P
Med Sci (Paris)
. 2021 Dec;
37(12):1101-1107.
PMID: 34928212
Exosomes are small extracellular vesicles derived from endosomal compartments. The molecular mechanisms supporting the biology of exosomes, from their biogenesis to their internalization by target cells, rely on 'dedicated' membrane...
8.
Garcia M, Hoffer L, Leblanc R, Benmansour F, Feracci M, Derviaux C, et al.
Eur J Med Chem
. 2021 Jun;
223:113601.
PMID: 34153575
Syntenin stimulates exosome production and its expression is upregulated in many cancers and implicated in the spread of metastatic tumor. These effects are supported by syntenin PDZ domains interacting with...
9.
Zimmermann P, Egea-Jimenez A
Methods Mol Biol
. 2021 May;
2256:75-87.
PMID: 34014517
Surface plasmon resonance (SPR)/BIAcore technology enables the characterization of molecular interactions, including determination of affinities and kinetics. In BIAcore, one of the interaction partners (the ligand) is immobilized on a...
10.
Castro-Cruz M, Monserrat-Gomez M, Borg J, Zimmermann P, Bailly E
Methods Mol Biol
. 2021 May;
2256:1-15.
PMID: 34014513
The yeast two-hybrid technique is a powerful method to detect direct protein-protein interactions. Due to its accessibility, speed, and versatility, this technique is easy to set up in any laboratory...