Ylva Ivarsson
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Explore the profile of Ylva Ivarsson including associated specialties, affiliations and a list of published articles.
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71
Citations
2305
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Recent Articles
1.
Ord M, Winters M, Subbanna M, Garrido N, Cushing V, Kliche J, et al.
bioRxiv
. 2024 Dec;
PMID: 39677664
Cyclin-CDKs are master regulators of cell division. In addition to directly activating the CDK, the cyclin subunit regulates CDK specificity by binding short peptide "docking" motifs in CDK substrates. Here,...
2.
Kliche J, Simonetti L, Krystkowiak I, Kuss H, Diallo M, Rask E, et al.
Mol Syst Biol
. 2024 Jul;
20(9):1025-1048.
PMID: 39009827
Whole genome and exome sequencing are reporting on hundreds of thousands of missense mutations. Taking a pan-disease approach, we explored how mutations in intrinsically disordered regions (IDRs) break or generate...
3.
Zhang Y, Xie G, Lee J, Zandian M, Sudarshan D, Estavoyer B, et al.
Nat Commun
. 2024 Jun;
15(1):4883.
PMID: 38849395
The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers....
4.
Becht D, Abdul Mohid S, Lee J, Zandian M, Benz C, Biswas S, et al.
Structure
. 2024 Apr;
32(6):706-714.e3.
PMID: 38579707
Human mixed lineage leukemia 4 (MLL4), also known as KMT2D, regulates cell type specific transcriptional programs through enhancer activation. Along with the catalytic methyltransferase domain, MLL4 contains seven less characterized...
5.
Mihalic F, Benz C, Kassa E, Lindqvist R, Simonetti L, Inturi R, et al.
Nat Commun
. 2023 Sep;
14(1):5636.
PMID: 37704626
The virus life cycle depends on host-virus protein-protein interactions, which often involve a disordered protein region binding to a folded protein domain. Here, we used proteomic peptide phage display (ProP-PD)...
6.
Blankenship C, Xie J, Benz C, Wang A, Ivarsson Y, Jiang J
Nat Chem Biol
. 2023 Aug;
19(11):1423-1431.
PMID: 37653170
The modification of intracellular proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) moieties is a highly dynamic process that spatiotemporally regulates nearly every important cellular program. Despite its significance, little is known about...
7.
Ali M, Khramushin A, Yadav V, Schueler-Furman O, Ivarsson Y
Biochemistry
. 2023 May;
62(11):1594-1607.
PMID: 37224425
The ERM (ezrin, radixin, and moesin) family of proteins and the related protein merlin participate in scaffolding and signaling events at the cell cortex. The proteins share an N-terminal FERM...
8.
Kliche J, Garvanska D, Simonetti L, Badgujar D, Dobritzsch D, Nilsson J, et al.
Mol Syst Biol
. 2023 May;
19(7):e11164.
PMID: 37219487
Phosphorylation is a ubiquitous post-translation modification that regulates protein function by promoting, inhibiting or modulating protein-protein interactions. Hundreds of thousands of phosphosites have been identified but the vast majority have...
9.
Mihalic F, Simonetti L, Giudice G, Rubin Sander M, Lindqvist R, Peters M, et al.
Nat Commun
. 2023 Apr;
14(1):2409.
PMID: 37100772
Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic intervention. Here,...
10.
Davey N, Simonetti L, Ivarsson Y
Curr Opin Struct Biol
. 2023 Apr;
80:102593.
PMID: 37099901
Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs...