Pascal Bonnet
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Explore the profile of Pascal Bonnet including associated specialties, affiliations and a list of published articles.
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74
Citations
620
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Recent Articles
11.
Avula S, Peng X, Lang X, Tortorella M, Josselin B, Bach S, et al.
J Enzyme Inhib Med Chem
. 2022 Jun;
37(1):1632-1650.
PMID: 35670091
A library of substituted indolo[2,3-]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, and a reduction/lactamization...
12.
Miret-Casals L, Van De Putte S, Aerssens D, Diharce J, Bonnet P, Madder A
Front Chem
. 2022 Mar;
9:799706.
PMID: 35252125
Using a coiled-coil peptide dimer as a model system to explore furan reactivity, we describe novel cross-link partners of furan warheads for site-specific cross-linking. We demonstrate that replacement of weak...
13.
Buron F, Rodrigues N, Saurat T, Hiebel M, Bourg S, Bonnet P, et al.
Molecules
. 2021 Sep;
26(17).
PMID: 34500781
This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-]pyrimidines. The series synthesized offers a chemical diversity...
14.
Elie J, Feizbakhsh O, Desban N, Josselin B, Baratte B, Bescond A, et al.
J Enzyme Inhib Med Chem
. 2020 Oct;
35(1):1840-1853.
PMID: 33040634
Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based...
15.
Bournez C, Carles F, Peyrat G, Aci-Seche S, Bourg S, Meyer C, et al.
Molecules
. 2020 Jul;
25(14).
PMID: 32679723
Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors are...
16.
Ibrahim N, Bonnet P, Brion J, Peyrat J, Bignon J, Levaique H, et al.
Eur J Med Chem
. 2020 May;
199:112355.
PMID: 32402934
In this work, unique flavopiridol analogs bearing thiosugars, amino acids and heterocyclic moieties tethered to the flavopiridol via thioether and amine bonds mainly on its C ring have been prepared....
17.
Bosc N, Muller C, Hoffer L, Lagorce D, Bourg S, Derviaux C, et al.
ACS Chem Biol
. 2020 Apr;
15(6):1566-1574.
PMID: 32320205
Protein-protein interactions (PPIs) mediate nearly every cellular process and represent attractive targets for modulating disease states but are challenging to target with small molecules. Despite this, several PPI inhibitors (iPPIs)...
18.
Fogha J, Diharce J, Obled A, Aci-Seche S, Bonnet P
ACS Omega
. 2020 Feb;
5(5):2114-2122.
PMID: 32064372
Allosteric effect can modulate the biological activity of a protein. Thus, the discovery of new allosteric sites is very attractive for designing new modulators or inhibitors. Here, we propose an...
19.
Braka A, Garnier N, Bonnet P, Aci-Seche S
J Chem Inf Model
. 2019 Dec;
60(1):342-348.
PMID: 31834793
In the early stage of a drug discovery process, the selection and optimization of a ligand is mainly based on equilibrium thermodynamic constants such as or IC values, which are...
20.
Raimbault A, Ma C, Ferri M, Baurer S, Bonnet P, Bourg S, et al.
J Chromatogr A
. 2019 Nov;
1612:460689.
PMID: 31733894
Chiralpak ZWIX(+) and ZWIX(-), are brush-type bonded-silica chiral stationary phases (CSPs), based on complex diastereomeric Cinchona alkaloids derivatives bearing both a positive and a negative charge. In the present study,...