Dirk Brehmer
Overview
Explore the profile of Dirk Brehmer including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
1013
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0
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Recent Articles
1.
Obermajer N, Zwolak A, van de Ven K, Versmissen S, Menard K, Rogers K, et al.
iScience
. 2025 Mar;
28(3):111876.
PMID: 40060890
T cell-redirecting bispecific antibodies (bsAbs) to treat advanced stage solid tumors are gaining interest after recent clinical successes. The immune checkpoint human leukocyte antigen G (HLA-G) is expressed in several...
2.
Arora R, Linders J, Aci-Seche S, Verheyen T, Van Heerde E, Brehmer D, et al.
Eur J Med Chem
. 2023 Mar;
250:115231.
PMID: 36878151
The mutation V600E in B-Raf leads to mitogen activated protein kinase (MAPK) pathway activation, uncontrolled cell proliferation, and tumorigenesis. ATP competitive type I B-Raf inhibitors, such as vemurafenib (1) and...
3.
Brehmer D, Beke L, Wu T, Millar H, Moy C, Sun W, et al.
Mol Cancer Ther
. 2021 Sep;
20(12):2317-2328.
PMID: 34583982
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required...
4.
Pande V, Sun W, Beke L, Berthelot D, Brehmer D, Brown D, et al.
ACS Med Chem Lett
. 2020 Nov;
11(11):2227-2231.
PMID: 33214833
Protein arginine methyltransferase 5 (PRMT5) is an enzyme that can symmetrically dimethylate arginine residues in histones and nonhistone proteins by using -adenosyl methionine (SAM) as the methyl donating cofactor. We...
5.
Beke L, Kig C, Linders J, Boens S, Boeckx A, Van Heerde E, et al.
Biosci Rep
. 2018 Dec;
38(6).
PMID: 30504271
No abstract available.
6.
Janes M, Zhang J, Li L, Hansen R, Peters U, Guo X, et al.
Cell
. 2018 Jan;
172(3):578-589.e17.
PMID: 29373830
KRAS was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active...
7.
Kig C, Beullens M, Beke L, Van Eynde A, Linders J, Brehmer D, et al.
J Biol Chem
. 2017 Aug;
292(31):12786.
PMID: 28778883
No abstract available.
8.
Arora R, Di Michele M, Stes E, Vandermarliere E, Martens L, Gevaert K, et al.
J Med Chem
. 2016 Jul;
59(14):6973.
PMID: 27385554
No abstract available.
9.
Wandinger S, Lahortiga I, Jacobs K, Klammer M, Jordan N, Elschenbroich S, et al.
PLoS One
. 2016 Jan;
11(1):e0146100.
PMID: 26745281
The four members of the epidermal growth factor receptor (EGFR/ERBB) family form homo- and heterodimers which mediate ligand-specific regulation of many key cellular processes in normal and cancer tissues. While...
10.
Beke L, Kig C, Linders J, Boens S, Boeckx A, Van Heerde E, et al.
Biosci Rep
. 2015 Oct;
35(6).
PMID: 26431963
Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has oncogenic properties and is overexpressed in many cancer cells. The oncogenic function of MELK is attributed to its capacity...