Paolo Armando Gagliardi
Overview
Explore the profile of Paolo Armando Gagliardi including associated specialties, affiliations and a list of published articles.
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29
Citations
634
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Recent Articles
1.
Dobrzynski M, Gradel B, Gagliardi P, Pertz O
Methods Microsc
. 2024 Aug;
1(1):19-30.
PMID: 39119253
Live-cell imaging of fluorescent biosensors has demonstrated that space-time correlations in signalling of cell collectives play an important organisational role in morphogenesis, wound healing, regeneration, and maintaining epithelial homeostasis. Here,...
2.
Gagliardi P, Pertz O
Curr Opin Cell Biol
. 2024 May;
88:102368.
PMID: 38754355
The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling network is a key transducer of signals from various receptors, including receptor tyrosine kinases (RTKs). It controls cell-cycle entry, survival, motility,...
3.
Pulfer A, Pizzagalli D, Gagliardi P, Hinderling L, Lopez P, Zayats R, et al.
Elife
. 2024 Mar;
12.
PMID: 38497754
Intravital microscopy has revolutionized live-cell imaging by allowing the study of spatial-temporal cell dynamics in living animals. However, the complexity of the data generated by this technology has limited the...
4.
Gagliardi P, Gradel B, Jacques M, Hinderling L, Ender P, Cohen A, et al.
J Cell Biol
. 2023 Jul;
222(10).
PMID: 37516918
Increasing experimental evidence points to the physiological importance of space-time correlations in signaling of cell collectives. From wound healing to epithelial homeostasis to morphogenesis, coordinated activation of biomolecules between cells...
5.
Nalecz-Jawecki P, Gagliardi P, Kochanczyk M, Dessauges C, Pertz O, Lipniacki T
PLoS Comput Biol
. 2023 May;
19(5):e1011155.
PMID: 37216347
Living cells utilize signaling pathways to sense, transduce, and process information. As the extracellular stimulation often has rich temporal characteristics which may govern dynamic cellular responses, it is important to...
6.
Ender P, Gagliardi P, Dobrzynski M, Frismantiene A, Dessauges C, Hohener T, et al.
Dev Cell
. 2022 Sep;
57(18):2153-2167.e6.
PMID: 36113484
The signaling events controlling proliferation, survival, and apoptosis during mammary epithelial acinar morphogenesis remain poorly characterized. By imaging single-cell ERK activity dynamics in MCF10A acini, we find that these fates...
7.
Hohener T, Landolt A, Dessauges C, Hinderling L, Gagliardi P, Pertz O
Sci Rep
. 2022 Jul;
12(1):13139.
PMID: 35907941
Optogenetics has become a key tool to manipulate biological processes with high spatio-temporal resolution. Recently, a number of commercial and open-source multi-well illumination devices have been developed to provide throughput...
8.
Dessauges C, Mikelson J, Dobrzynski M, Jacques M, Frismantiene A, Gagliardi P, et al.
Mol Syst Biol
. 2022 Jun;
18(6):e10670.
PMID: 35694820
Combining single-cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an...
9.
Gagliardi P, Dobrzynski M, Jacques M, Dessauges C, Ender P, Blum Y, et al.
Dev Cell
. 2021 Jun;
56(12):1712-1726.e6.
PMID: 34081908
Cell death events continuously challenge epithelial barrier function yet are crucial to eliminate old or critically damaged cells. How such apoptotic events are spatio-temporally organized to maintain epithelial homeostasis remains...
10.
Jacques M, Dobrzynski M, Gagliardi P, Sznitman R, Pertz O
Mol Syst Biol
. 2021 Apr;
17(4):e10026.
PMID: 33835701
Current studies of cell signaling dynamics that use live cell fluorescent biosensors routinely yield thousands of single-cell, heterogeneous, multi-dimensional trajectories. Typically, the extraction of relevant information from time series data...