Paolo Armando Gagliardi
Overview
Explore the profile of Paolo Armando Gagliardi including associated specialties, affiliations and a list of published articles.
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29
Citations
634
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Recent Articles
11.
Lupo B, Sassi F, Pinnelli M, Galimi F, Zanella E, Vurchio V, et al.
Sci Transl Med
. 2020 Aug;
12(555).
PMID: 32759276
Blockade of epidermal growth factor receptor (EGFR) causes tumor regression in some patients with metastatic colorectal cancer (mCRC). However, residual disease reservoirs typically remain even after maximal response to therapy,...
12.
Somale D, Di Nardo G, di Blasio L, Puliafito A, Vara-Messler M, Chiaverina G, et al.
Sci Rep
. 2020 Jan;
10(1):591.
PMID: 31953410
The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation loop and on the hydrophobic motif, respectively....
13.
Gagliardi P, Primo L
Cell Mol Life Sci
. 2019 May;
76(18):3571-3581.
PMID: 31143959
Apoptosis plays a crucial role in clearing old or critically compromised cells, and actively maintains epithelial homeostasis and epithelial morphogenesis during embryo development. But how is the apoptotic signaling pathway...
14.
Gagliardi P, Pertz O
Dev Cell
. 2019 Feb;
48(3):289-290.
PMID: 30753833
How a small number of signaling pathways can be re-used in distinct embryonic contexts to control different fates remains unclear. In this issue of Developmental Cell, Johnson and Toettcher (2019)...
15.
Gagliardi P, Primo L
Mol Biol Evol
. 2018 Dec;
36(2):376-392.
PMID: 30517755
Activation of Rho-associated protein kinase 1 (ROCK1) and myotonic dystrophy kinase-related CDC42-binding kinase alpha (MRCKα) by caspases during apoptosis in vertebrates represents a prototypical example of co-option of kinases by...
16.
di Blasio L, Puliafito A, Gagliardi P, Comunanza V, Somale D, Chiaverina G, et al.
Cell Death Dis
. 2018 Jan;
9(2):45.
PMID: 29352118
Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and...
17.
Gagliardi P, Somale D, Puliafito A, Chiaverina G, di Blasio L, Oneto M, et al.
J Cell Biol
. 2017 Nov;
217(1):231-249.
PMID: 29162624
Extrusion of apoptotic cells from epithelial tissues requires orchestrated morphological rearrangements of the apoptotic cell and its neighbors. However, the connections between the apoptotic cascade and events leading to extrusion...
18.
Gagliardi P, Puliafito A, Primo L
Semin Cancer Biol
. 2017 May;
48:27-35.
PMID: 28473254
Rational target therapy of cancer would benefit from the identification of new targets that can be easily inhibited by small molecules. An increasing amount of evidence hints at 3-phosphoinositide dependent...
19.
Torchiaro E, Lorenzato A, Olivero M, Valdembri D, Gagliardi P, Gai M, et al.
Oncotarget
. 2015 Dec;
7(1):712-28.
PMID: 26625210
The molecular mechanisms orchestrating peritoneal and hematogenous metastases of ovarian cancer cells are assumed to be distinct. We studied the p90RSK family of serine/threonine kinases that lie downstream the RAS-ERK/MAPK...
20.
Puliafito A, Simone A, Seano G, Gagliardi P, di Blasio L, Chianale F, et al.
Sci Rep
. 2015 Oct;
5:15205.
PMID: 26471876
One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion...