P Mantsala
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Explore the profile of P Mantsala including associated specialties, affiliations and a list of published articles.
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66
Citations
592
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Recent Articles
1.
Kantola J, Kunnari T, Mantsala P, Ylihonkoa K
Comb Chem High Throughput Screen
. 2003 Oct;
6(6):501-12.
PMID: 14529376
Combinatorial biosynthesis is a technology for mixing genes responsible for the biosynthesis of secondary metabolites, in order to generate products for compound libraries serendipitously or to cause desired modifications to...
2.
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
Mol Genet Genomics
. 2001 Oct;
266(2):276-88.
PMID: 11683270
Fragments spanning 20 kb of Streptomyces nogalater genomic DNA were characterized to elucidate the molecular genetic basis of the biosynthetic pathway of the anthracycline antibiotic nogalamycin. Structural analysis of the...
3.
Raty K, Kunnari T, Hakala J, Mantsala P, Ylihonko K
Mol Gen Genet
. 2000 Oct;
264(1-2):164-72.
PMID: 11016846
We have cloned and characterized a gene cluster for anthracycline biosynthesis from Streptomyces galilaeus. This cluster, 15-kb long, includes eight genes involved in the deoxyhexose biosynthesis pathway, a gene for...
4.
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
Biochim Biophys Acta
. 2000 Sep;
1480(1-2):191-200.
PMID: 11004563
The genes rdmB and rdmC of Streptomyces purpurascens encoding aclacinomycin modifying enzymes RdmB and RdmC were expressed in Streptomyces lividans TK24. In contrast to the earlier suggestion that RdmC may...
5.
Torkkell S, Kunnari T, Palmu K, Hakala J, Mantsala P, Ylihonko K
Antimicrob Agents Chemother
. 2000 Jan;
44(2):396-9.
PMID: 10639368
Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene...
6.
Sinha S, Rappu P, Lange S, Mantsala P, ZALKIN H, Smith J
Proc Natl Acad Sci U S A
. 1999 Nov;
96(23):13074-9.
PMID: 10557275
The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is...
7.
Metsa-Ketela M, Salo V, Halo L, Hautala A, Hakala J, Mantsala P, et al.
FEMS Microbiol Lett
. 1999 Nov;
180(1):1-6.
PMID: 10547437
Degenerated oligonucleotide primers were designed to amplify fragments of ketosynthase genes from polyketide antibiotics producing Streptomyces spp. and bacterial strains enriched from soil samples. Cell lysates were used as templates...
8.
Kunnari T, Ylihonko K, Hautala A, Klika K, Mantsala P, Hakala J
Bioorg Med Chem Lett
. 1999 Oct;
9(18):2639-42.
PMID: 10509907
Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the...
9.
Rappu P, Shin B, ZALKIN H, Mantsala P
J Bacteriol
. 1999 Jun;
181(12):3810-5.
PMID: 10368157
Regulation of the purine biosynthetic gene purA was examined by using a transcriptional fusion to a luciferase reporter gene. Transcription was repressed about 10-fold by the addition of adenine and...
10.
Ollikka P, Harjunpaa T, Palmu K, Mantsala P, Suominen I
Appl Biochem Biotechnol
. 1999 May;
75(2-3):307-21.
PMID: 10230025
The ligninolytic enzyme system of Phanerochaete chrysosporium is able to decolorize several recalcitrant dyes. Three lignin peroxidase isoenzymes, LiP 3.85, LiP 4.15, and LiP 4.65, were purified by preparative isoelectric...