K Ylihonko
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Explore the profile of K Ylihonko including associated specialties, affiliations and a list of published articles.
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14
Citations
191
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Recent Articles
1.
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
Mol Genet Genomics
. 2001 Oct;
266(2):276-88.
PMID: 11683270
Fragments spanning 20 kb of Streptomyces nogalater genomic DNA were characterized to elucidate the molecular genetic basis of the biosynthetic pathway of the anthracycline antibiotic nogalamycin. Structural analysis of the...
2.
Raty K, Kunnari T, Hakala J, Mantsala P, Ylihonko K
Mol Gen Genet
. 2000 Oct;
264(1-2):164-72.
PMID: 11016846
We have cloned and characterized a gene cluster for anthracycline biosynthesis from Streptomyces galilaeus. This cluster, 15-kb long, includes eight genes involved in the deoxyhexose biosynthesis pathway, a gene for...
3.
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
Biochim Biophys Acta
. 2000 Sep;
1480(1-2):191-200.
PMID: 11004563
The genes rdmB and rdmC of Streptomyces purpurascens encoding aclacinomycin modifying enzymes RdmB and RdmC were expressed in Streptomyces lividans TK24. In contrast to the earlier suggestion that RdmC may...
4.
Torkkell S, Kunnari T, Palmu K, Hakala J, Mantsala P, Ylihonko K
Antimicrob Agents Chemother
. 2000 Jan;
44(2):396-9.
PMID: 10639368
Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene...
5.
Metsa-Ketela M, Salo V, Halo L, Hautala A, Hakala J, Mantsala P, et al.
FEMS Microbiol Lett
. 1999 Nov;
180(1):1-6.
PMID: 10547437
Degenerated oligonucleotide primers were designed to amplify fragments of ketosynthase genes from polyketide antibiotics producing Streptomyces spp. and bacterial strains enriched from soil samples. Cell lysates were used as templates...
6.
Kunnari T, Ylihonko K, Hautala A, Klika K, Mantsala P, Hakala J
Bioorg Med Chem Lett
. 1999 Oct;
9(18):2639-42.
PMID: 10509907
Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the...
7.
Niemi J, Wang Y, Airas K, Ylihonko K, Hakala J, Mantsala P
Biochim Biophys Acta
. 1999 Mar;
1430(1):57-64.
PMID: 10082933
Aklavinone-11-hydroxylase (RdmE) is a FAD monooxygenase participating in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The rdmE gene encodes an enzyme of 535 amino acids. The sequence of the Streptomyces...
8.
Torkkell S, Ylihonko K, Hakala J, Skurnik M, Mantsala P
Mol Gen Genet
. 1998 Feb;
256(2):203-9.
PMID: 9349712
The sno gene cluster in Streptomyces nogalater ATCC 27451 contains the nogalamycin biosynthesis genes. A set of plasmid constructions carrying fragments of the sno cluster that lie downstream of snoD...
9.
Kantola J, Blanco G, Hautala A, Kunnari T, Hakala J, Mendez C, et al.
Chem Biol
. 1997 Dec;
4(10):751-5.
PMID: 9375253
Background: Mithramycin, nogalamycin and aclacinomycins are aromatic polyketide antibiotics that exhibit antitumour activity. The precursors of these antibiotics are formed via a polyketide biosynthetic pathway in which acetate (for mithramycinone...
10.
Kunnari T, Tuikkanen J, Hautala A, Hakala J, Ylihonko K, Mantsala P
J Antibiot (Tokyo)
. 1997 Jun;
50(6):496-501.
PMID: 9268006
Streptomyces steffisburgensis (NRRL 3193, ATCC 27466) is described as a steffimycin producer. Steffimycin belongs to the anthracycline group of aromatic polyketide antibiotics. The structural analysis of the products accumulated by...