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P Krogsgaard-Larsen

Explore the profile of P Krogsgaard-Larsen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 203
Citations 1551
Followers 0
Related Specialties
Chemistry
Pharmacology
Neurology
Top 10 Co-Authors
E Falch
B Ebert
A Schousboe
U Madsen
H Brauner-Osborne
T B Stensbol
T N Johansen
D R Curtis
L BREHM
J J Hansen
Published In
J Med Chem
J Neurochem
Eur J Pharmacol
Adv Biochem Psychopharmacol
Chirality
Affiliations
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Recent Articles
1.
The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors
Hoestgaard-Jensen K, OConnor R, Dalby N, Simonsen C, Finger B, Golubeva A, et al.
Br J Pharmacol . 2013 Aug; 170(4):919-32. PMID: 23957253
Background And Purpose: Explorations into the heterogeneous population of native GABA type A receptors (GABAA Rs) and the physiological functions governed by the multiple GABAA R subtypes have for decades...
2.
Characterization of the uptake of GABA, nipecotic acid and cis-4-OH-nipecotic acid in cultured neurons and astrocytes
Larsson O, Krogsgaard-Larsen P, Schousboe A
Neurochem Int . 2010 May; 7(5):853-60. PMID: 20492996
The transport kinetics of GABA, (RS)-nipecotic acid and (3RS, 4SR)-4-hydroxynipecotic acid and the mutual inhibition patterns of these compounds were investigated in cultured cerebral cortex neurons and astrocytes together with...
3.
Lack of a high affinity uptake system for the GABA agonists THIP and isoguvacine in neurons and astrocytes cultured from mouse brain
Schousboe A, Larsson O, Krogsgaard-Larsen P
Neurochem Int . 2010 May; 7(3):505-8. PMID: 20492954
The possibility that the GABA-receptor agonists isoguvacine and THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) might be taken up into brain cells via the high affinity GABA transport system was tested by incubation of cultured...
4.
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
Mellor I, Brier T, Pluteanu F, Stromgaard K, Saghyan A, Eldursi N, et al.
Neuropharmacology . 2003 Feb; 44(1):70-80. PMID: 12559123
Voltage-dependent, non-competitive inhibition by philanthotoxin-343 (PhTX-343) analogues, with reduced charge or length, of nicotinic acetylcholine receptors (nAChR) of TE671 cells and ionotropic glutamate receptors (N-methyl-D-aspartate receptors (NMDAR) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid...
5.
Recent advances in the medicinal chemistry of polyamine toxins
Stromgaard K, Andersen K, Krogsgaard-Larsen P, Jaroszewski J
Mini Rev Med Chem . 2002 Oct; 1(4):317-38. PMID: 12369960
This review describes the recent developments in the field of polyamine toxins, with focus on structure activity relationship investigations, including studies of importance of the polyamine moiety for biological activity,...
6.
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA
Johansen T, Stensbol T, Nielsen B, Vogensen S, Frydenvang K, Slok F, et al.
Chirality . 2001 Oct; 13(9):523-32. PMID: 11579444
We have previously described (RS)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) as a potent agonist at the (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor subtype of (S)-glutamic acid (Glu) receptors. We now report the chromatographic resolution of...
7.
Inhibitors of AMPA and kainate receptors
Madsen U, Stensbol T, Krogsgaard-Larsen P
Curr Med Chem . 2001 Sep; 8(11):1291-301. PMID: 11562267
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or...
8.
Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol
Bunch L, Norrby P, Frydenvang K, Krogsgaard-Larsen P, Madsen U
Org Lett . 2001 Jun; 3(3):433-5. PMID: 11428032
[figure: see text] Cleavage of an O-silyl ether in an N-BOC-protected pyroglutaminol using TBAF led to an unprecedented migration of the BOC group. An investigation of the mechanism, based on...
9.
Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors
Ebert B, Mortensen M, Thompson S, Kehler J, Wafford K, Krogsgaard-Larsen P
Bioorg Med Chem Lett . 2001 Jun; 11(12):1573-7. PMID: 11412984
The potency and efficacy of a series of bioisosterically modified GABA analogues were determined electrophysiologically using heteromeric GABA(A) receptors expressed in Xenopus oocytes. These agonist parameters were shown to be...
10.
Synthesis and receptor binding affinity of new selective GluR5 ligands
Bunch L, Johansen T, Brauner-Osborne H, Stensbol T, Johansen T, Krogsgaard-Larsen P, et al.
Bioorg Med Chem . 2001 May; 9(4):875-9. PMID: 11354670
Two hybrid analogues of the kainic acid receptor agonists, 2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA) and (2S,4R)-4-methylglutamic acid ((2S,4R)-4-Me-Glu), were designed, synthesized, and characterized in radioligand binding assays using cloned ionotropic and metabotropic...