P Jeremy Wang
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Explore the profile of P Jeremy Wang including associated specialties, affiliations and a list of published articles.
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64
Citations
1984
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Recent Articles
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Chotiner J, Leu N, Yang F, Cossu I, Guan Y, Lin H, et al.
Elife
. 2024 Aug;
12.
PMID: 39207914
Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. Mouse TRIP13 and its ortholog Pch2 are instrumental in remodeling HORMA domain proteins....
3.
Cossu I, Leu N, Guan Y, Wang P
Reproduction
. 2024 Feb;
167(4).
PMID: 38401263
In Brief: The dissociation of HORMA domain protein 2 (HORMAD2) from the synaptonemal complex is tightly regulated. This study reveals that the N-terminal region of HORMAD2 is critical for its...
4.
Wong H, Chen T, Wang P, Holzman L
Dev Biol
. 2024 Jan;
508:46-63.
PMID: 38242343
Male germ cells are connected by intercellular bridges (ICBs) in a syncytium due to incomplete cytokinesis. Syncytium is thought to be important for synchronized germ cell development by interchange of...
5.
Chotiner J, Leu N, Yang F, Cossu I, Guan Y, Lin H, et al.
bioRxiv
. 2023 Oct;
PMID: 37808842
Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. The AAA+ ATPase TRIP13 and its orthologue Pch2 are instrumental in remodeling HORMA...
6.
Miao X, Guo R, Williams A, Lee C, Ma J, Wang P, et al.
bioRxiv
. 2023 Jul;
PMID: 37461444
Persistence of unrepaired DNA damage in oocytes is detrimental and may cause genetic aberrations, miscarriage, and infertility. RPA, an ssDNA-binding complex, is essential for various DNA-related processes. Here we report...
7.
Guan Y, Gao H, Leu N, Vourekas A, Alexiou P, Maragkakis M, et al.
PLoS Genet
. 2023 May;
19(5):e1010566.
PMID: 37126510
Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements,...
8.
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis
Lin H, Cossu I, Leu N, Deshpande A, Bernt K, Luo M, et al.
Development
. 2023 Apr;
150(9).
PMID: 37082953
Histone modifications regulate chromatin remodeling and gene expression in development and diseases. DOT1L, the sole histone H3K79 methyltransferase, is essential for embryonic development. Here, we report that DOT1L regulates male...
9.
Peart N, Johnson T, Lee S, Sears M, Yang F, Quesnel-Vallieres M, et al.
PLoS Genet
. 2022 Sep;
18(9):e1010416.
PMID: 36129965
Control over gene expression is exerted, in multiple stages of spermatogenesis, at the post-transcriptional level by RNA binding proteins (RBPs). We identify here an essential role in mammalian spermatogenesis and...
10.
Lin H, Cheng K, Kubota H, Lan Y, Riedel S, Kakiuchi K, et al.
Genes Dev
. 2022 Jun;
36(11-12):752-763.
PMID: 35738678
Self-renewal of spermatogonial stem cells is vital to lifelong production of male gametes and thus fertility. However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79...