N Adrian Leu
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Explore the profile of N Adrian Leu including associated specialties, affiliations and a list of published articles.
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68
Citations
2500
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Recent Articles
1.
Chotiner J, Leu N, Yang F, Cossu I, Guan Y, Lin H, et al.
Elife
. 2024 Aug;
12.
PMID: 39207914
Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. Mouse TRIP13 and its ortholog Pch2 are instrumental in remodeling HORMA domain proteins....
2.
Prasasya R, Caldwell B, Liu Z, Wu S, Leu N, Fowler J, et al.
Dev Cell
. 2024 Apr;
59(8):1010-1027.e8.
PMID: 38569549
Ten-eleven translocation (TET) enzymes iteratively oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine to facilitate active genome demethylation. Whether these bases are required to promote replication-coupled dilution or...
3.
Cossu I, Leu N, Guan Y, Wang P
Reproduction
. 2024 Feb;
167(4).
PMID: 38401263
In Brief: The dissociation of HORMA domain protein 2 (HORMAD2) from the synaptonemal complex is tightly regulated. This study reveals that the N-terminal region of HORMAD2 is critical for its...
4.
Gao S, Tang A, Wang M, Buchholz D, Imbiakha B, Yang J, et al.
Front Cardiovasc Med
. 2023 Oct;
10:1266276.
PMID: 37823176
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how severe acute respiratory syndrome coronavirus 2...
5.
Chotiner J, Leu N, Yang F, Cossu I, Guan Y, Lin H, et al.
bioRxiv
. 2023 Oct;
PMID: 37808842
Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. The AAA+ ATPase TRIP13 and its orthologue Pch2 are instrumental in remodeling HORMA...
6.
Gao S, Tang A, Wang M, Buchholz D, Imbiakha B, Yang J, et al.
bioRxiv
. 2023 Aug;
PMID: 37546961
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how Severe Acute Respiratory Syndrome Coronavirus 2...
7.
Guan Y, Gao H, Leu N, Vourekas A, Alexiou P, Maragkakis M, et al.
PLoS Genet
. 2023 May;
19(5):e1010566.
PMID: 37126510
Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements,...
8.
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis
Lin H, Cossu I, Leu N, Deshpande A, Bernt K, Luo M, et al.
Development
. 2023 Apr;
150(9).
PMID: 37082953
Histone modifications regulate chromatin remodeling and gene expression in development and diseases. DOT1L, the sole histone H3K79 methyltransferase, is essential for embryonic development. Here, we report that DOT1L regulates male...
9.
Zhu X, Xu M, Leu N, Morrisey E, Millar S
Dis Model Mech
. 2023 Mar;
16(3).
PMID: 36867021
Human Robinow syndrome (RS) and dominant omodysplasia type 2 (OMOD2), characterized by skeletal limb and craniofacial defects, are associated with heterozygous mutations in the Wnt receptor FZD2. However, as FZD2...
10.
Tang A, Buchholz D, Szigety K, Imbiakha B, Gao S, Frankfurter M, et al.
PLoS Biol
. 2023 Feb;
21(2):e3001989.
PMID: 36745682
Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus Disease 2019 (COVID-19) pathogenesis is indisputable, there remains...