P J Owen-Lynch
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Explore the profile of P J Owen-Lynch including associated specialties, affiliations and a list of published articles.
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21
Citations
168
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Recent Articles
1.
Iatsenko D, Bernjak A, Stankovski T, Shiogai Y, Owen-Lynch P, Clarkson P, et al.
Philos Trans A Math Phys Eng Sci
. 2013 Jul;
371(1997):20110622.
PMID: 23858485
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16-90. By application of the synchrosqueezed wavelet transform, we extract the respiratory...
2.
Robinson S, Sunram-Lea S, Leach J, Owen-Lynch P
Stress
. 2008 Mar;
11(2):115-24.
PMID: 18311600
Exposure to an acute naturalistic stressor induces both psychological and physiological changes in humans. The two studies reported here explored the impact of exposure to an acute naturalistic stressor on...
3.
Pierce A, Lu Y, Hamzah H, Thompson S, Owen-Lynch P, Whetton A, et al.
Br J Haematol
. 2006 Apr;
133(3):345-52.
PMID: 16643438
The chemokine, stromal cell-derived factor-1 (SDF-1) is a crucial regulator of stem cell homing and tethering, and potentiation of this pathway in leukaemias may contribute to the pathogenesis of the...
4.
Underhill-Day N, Pierce A, THOMPSON S, Xenaki D, Whetton A, Owen-Lynch P
Br J Haematol
. 2006 Feb;
132(6):774-83.
PMID: 16487179
Philadelphia chromosome-positive, chronic myeloid leukaemia (CML) stem and progenitor cells have a survival and growth advantage compared with their normal counterparts. The mechanisms through which the BCR/ABL protein tyrosine kinase...
5.
Draper C, Owen-Lynch P, Bannister C, Miyan J
Eur J Pediatr Surg
. 2002 Mar;
11 Suppl 1:S51-2.
PMID: 11887785
No abstract available.
6.
Bentley J, Walker I, McIntosh E, Whetton A, Owen-Lynch P, Baldwin S
Br J Haematol
. 2001 Feb;
112(1):212-5.
PMID: 11167806
The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr--Abl protein tyrosine kinase was...
7.
Pierce A, Spooncer E, Wooley S, Dive C, Francis J, Miyan J, et al.
Oncogene
. 2000 Dec;
19(48):5487-97.
PMID: 11114726
Chronic myeloid leukaemia is a haemopoietic stem cell disorder, the hallmark of which is the expression of the Bcr-Abl Protein Tyrosine Kinase (PTK). We have previously reported that activation of...
8.
Tang X, Downes C, Whetton A, Owen-Lynch P
J Biol Chem
. 2000 Apr;
275(17):13142-8.
PMID: 10777620
Leukemogenic oncogenes, such as the Abelson protein-tyrosine kinases (PTK), disrupt the normal regulation of survival, proliferation, and differentiation in hemopoietic progenitor cells. In the absence of cytokines, hemopoietic progenitor cells...
9.
Pearson M, OFarrell A, Dexter T, Whetton A, Owen-Lynch P, Heyworth C
Growth Factors
. 1998 Aug;
15(4):293-306.
PMID: 9714913
Stem Cell Factor (SCF), the ligand for the c-kit proto-oncogene, has been shown to synergistically interact with other cytokines, enhancing the responsiveness of haemopoietic precursors. In this study we have...
10.
Pierce A, Owen-Lynch P, Spooncer E, Dexter T, Whetton A
Oncogene
. 1998 Aug;
17(5):667-72.
PMID: 9704934
Chronic myeloid leukaemia (CML) is a clonal disorder of the pluripotent haemopoietic stem cell, the hallmark of which is the constitutively activated Bcr-Abl protein tyrosine kinase. During the initial chronic...